Prognostic Value of Non-invasive Index of Endothelial Function.

Status Completed

Clinical Trial Summary

The objective of this study is to determine the prognostic performance of endothelial function assessment, using endothelial peripheral arterial tonometry (Endo-PAT), associated to TIMI risk score, in patients consulting the emergency department for non-traumatic chest pain. To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose.

Clinical Trial Description

Chest pain is a frequent reason for consultation in the emergency room, which can be as much as 5 to 10% of consultants. Stratifying the cardiovascular risk for patients consulting for chest pain is sometimes difficult. The endothelium plays a crucial role in maintaining the tone and vascular integrity and in particular the secretion of vasodilator and vasoconstrictor mediators. In most vascular pathologies, this equilibrium will be broken by the attenuation of the vasodilating function of the endothelium. This is called endothelial dysfunction. Several tools for measuring endothelial function have been developed, the main characteristics of which are: noninvasive, reproducible, independent operators, predictive of the disease, safe for subjects, inexpensive and easy to use. In this study we will be interested in digital plethysmography which has shown its effectiveness in: - Screening for cardiovascular risk in asymptomatic subjects. - The risk of a new cardiovascular event in the sick. - Evaluation of the response to certain therapies. Goal of the study : The objective of this study is to to determine the prognostic performance of endothelial function assessment, using endothelial peripheral arterial tonometry (Endo-PAT), associated to TIMI risk score, in patients consulting the emergency department for non-traumatic chest pain. To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose, hence the originality of this study. ;

Study Design

Related Conditions & MeSH terms

Chest Pain
Major Adverse Cardiovascular Events

Clinical Trial Details

NCT number	NCT03164226
Study type	Interventional
Source	University of Monastir
Contact
Status	Completed
Phase	N/A
Start date	March 15, 2016
Completion date	September 15, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04153006` - Comparison of Fingerstick Versus Venous Sample for Troponin I.
Recruiting	`NCT03664973` - Serratus Plane Block for Rib Fractures	N/A
Completed	`NCT02905383` - The Effect of Exercise on Physical Function and Health in Older People After Discharge From Hospital	N/A
Not yet recruiting	`NCT05649891` - Checklists Resuscitation Emergency Department	N/A
Withdrawn	`NCT03906812` - A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain	N/A
Active, not recruiting	`NCT02892903` - In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?	N/A
Completed	`NCT02538861` - Acute Chest Pain Imaging in the ED With the Combine CCTA and CT Perfusion
Completed	`NCT02538770` - Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization	N/A
Completed	`NCT02440893` - Understanding the Effect of Metformin on Corus CAD (or ASGES)
Completed	`NCT01931852` - Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin	N/A
Completed	`NCT01665521` - Efficacy Evaluation of the HEART Pathway in Emergency Department Patients With Acute Chest Pain	N/A
Recruiting	`NCT01542086` - Comparison of the Cost-Effectiveness of Coronary CT Angiography Versus Myocardial SPECT in Patients With Intermediate Risk of Coronary Heart Disease	N/A
Completed	`NCT01486030` - Effect of Exercise Stress Testing on Peripheral Gene Expression Using Corus CAD (or ASGES) Diagnostic Test
Completed	`NCT01604655` - ProspEctive First Evaluation in Chest Pain Trial	N/A
Terminated	`NCT01836211` - High-Sensitivity Troponin T and Coronary Computed Tomography Angiography for Rapid Diagnosis of Emergency Chest Pain	N/A
Completed	`NCT01163019` - 2D Strain Echocardiography for Diagnosing Chest Pain in the Emergency Room	N/A
Completed	`NCT00709670` - ComParative Diagnostic Study Between Multislice Computed Tomography (MSCT) and Stress Echography in Coronarin Patients.	N/A
Completed	`NCT00536224` - Chest Pain Observation Unit Risk Reduction Trial	N/A
Terminated	`NCT00221182` - Stem Cell Study for Patients With Heart Disease	Phase 1/Phase 2
Completed	`NCT00075088` - Tele-Electrocardiography in Emergency Cardiac Care	Phase 3