Photobiomodulation Therapy in the Prevention and Management of Chemotherapy-Induced Alopecia — HairLight

Chemotherapy-induced Alopecia Clinical Trial

Official title:
Evaluating the Feasibility and Efficacy of Photobiomodulation Therapy in the Prevention and Management of Chemotherapy-induced Alopecia: a Randomized Controlled Trial

Status Recruiting

Clinical Trial Summary

This study aims to investigate the effectiveness of photobiomodulation therapy (PBM) in the prevention and management of chemotherapy-induced alopecia (CIA). Therefore, we hypothesize that PBMT can reduce the severity of CIA in gynecological and breast cancer patients, increasing the patient's QoL.

Clinical Trial Description

The global cancer burden keeps rising, and the accompanied side effects remain a significant concern. This project focuses on one of such complications: chemotherapy-induced alopecia (CIA). 65% of cancer patients receiving cytotoxic drugs experience CIA, which negatively impacts their QoL, as hair loss is often associated with impaired body image and increased depression rates. Up to now, prevention of CIA is based on scalp cooling, but this treatment has a highly variable success rate. Photobiomodulation (PBM) therapy is a non-invasive form of phototherapy that utilizes visible and/or near-infrared light to trigger a cascade of intracellular reactions. PBM can be used to improve wound healing, and to reduce pain, inflammation, and edema. Research shows that PBM can stimulate hair growth by increasing the blood flow to the scalp and stimulating the catagen or telogen metabolism of the hair follicle. However, the effect of PBM on CIA has not been adequately investigated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05177289
Study type	Interventional
Source	Jessa Hospital
Contact	Jeroen Mebis, Prof. Dr.
Phone	+32 11 33 72 21
Email	jeroen.mebis@jessazh.be
Status	Recruiting
Phase	N/A
Start date	February 28, 2022
Completion date	January 2030

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04986579` - Scalp Cooling in MBC	Phase 2
Recruiting	`NCT06215469` - Portable Scalp Cooling System (PSCS) to Prevent Hair Loss for Breast Cancer Patients (Cooler Heads)	N/A
Not yet recruiting	`NCT05484973` - Study to Assess the Ability of the Portable Scalp Cooling System (PSCS) to Prevent Hair Loss	N/A
Recruiting	`NCT06020586` - Study To Evaluate The Efficacy And Safety Profile of ECOHAIR in Chemo-induced Alopecia.	N/A
Recruiting	`NCT02797223` - "Impact of Chemotherapy-induced Alopecia on the Quality of Life of Women With Breast Cancer"	N/A
Recruiting	`NCT04036994` - PBMT for the Management of CIA ( HAIRLASER )	N/A
Completed	`NCT03712696` - Efficacy and Safety of DIGNICAP™ System	N/A
Recruiting	`NCT06011525` - Prevention of Alopecia in Patients With Localised Breast Cancer	N/A
Recruiting	`NCT05397457` - Effect of Helmet Type, Home-use Low-level Light Therapy Device for Chemotherapy-induced Alopecia	N/A
Withdrawn	`NCT05365243` - A Pilot Study to Evaluate the Use of the AMMA Portable Scalp Cooling System From Cooler Heads	N/A