Chemical Peeling Clinical Trial
Official title:
Hyperbaric Therapy and Healing From Deep Chemical Peel
To evaluate whether treatment with Hyperbaric oxygen can accelerate skin recovery after deep
peeling, and decrease frequency and severity of local side effects and complications.
20 post peel patients will recieve 5 daily hyperbaric treatments, starting from day 7 to
peel.Patient's followup will include self- filling questionnaire and photographs
The study will include 40 post-deep peel women (exoderm), older than 18 years old, treated
by the same dermatologist.
The treatment group will recieve 5 consecutive daily hyperbaric treatments, 1 hours long
each, at 2 ATF, starting from day 7 to peel. Prior to treatment, each patient will be signed
on informed consent and will have complete physical examination.
The control group will be matched by the following parameters: age, skin color and type, and
indication for peeling, and will be picked up by the dermatologist.
Patients will be excluded if they have known middle ear disease, chronic lung disease or
claustrophobia.
Follow -up:
The same dermatologist will follow-up, on regular dates: the follow-up examination will
start at day 1 to mask\occlusive dressing removal (equivalent to day 7 post-peel), and at
days 7, 28, and after 3 months. All follow-up examinations will take place at noon (04-08
pm) regularly.
Efficacy parameters:
All patients will be asked to fill up a daily questionnaire on the first week after peel,
and score the severity of pain, pruritus and tightness of facial skin (1 to 5). They will
also mention the daily analgesic usage.
Parameters that will be evaluated by the dermatologist during the study will be: tightness
of the skin, pain/burning, pruritus/stinging, swelling/edema, erythema, crusting, and
scaling, assessed on a 4-point severity scale (0- best, 3- worst).
Photographs:
Photographs of the patients in 5 angles views will be taken on the day of peel, day of mask
removal (7), day 28 and after 3 months.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment