Cesarean Section Complications Clinical Trial
Official title:
Vasopressor Prophylaxis After Spinal Anesthesia: A Dose Finding Study
Norepinephrine has been recently introduced as a prophylactic vasopressor during Cesarean delivery with promising results ; However, the optimum dose for efficient prophylaxis with the least side effects is not known. In this study, we will compare three doses (0.05, 0.1, 0.15 mcg/Kg/min) of norepinephrine for prophylaxis against Post-Spinal hypotension during cesarean delivery.
Maternal hypotension is a common complication after spinal anesthesia for cesarean delivery
(CD). Using vasopressors have been considered a gold standard for prevention of post-spinal
hypotension (PSH) during CD.
Norepinephrine (NE) is a potent vasopressor characterized by both α adrenergic agonistic
activity in addition to a weak β adrenergic agonistic activity; thus, NE is considered a
vasopressor with minimal cardiac depressant effect; these pharmacological properties would
make NE an attractive alternative to phenylephrine and ephedrine (the most commonly used
vasopressors in obstetric anesthesia).
Norepinephrine has been recently introduced as a prophylactic vasopressor during CD with
promising results; However, the optimum dose for efficient prophylaxis with the least side
effects is not known.
In this study, we will compare three doses (0.05, 0.1, 0.15 mcg/Kg/min) of norepinephrine for
prophylaxis against PSH during CD.
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