Cervical Intraepithelial Neoplasia Clinical Trial
Official title:
Clinical Study on the Regress of Cervical Intraepithelial Neoplastic(CIN) 1/CIN2 by Highly Effective DC Vaccines Targeting HPV E6/ E7 Protein
To establish therapeutic dendritic cell (DC) vaccines targeting HPV 16/18 E6/E7 protein to block the progression of CIN1/CIN2 to cervical cancer and evaluate the safety and efficacy of the vaccines.
Cervical cancer is the second most common cause of cancer-related deaths among women
worldwide with 10000 new cases each year in China. The high-risk human papillomavirus (HPV)
was the major cause of cervical cancer. The oncoproteins E6 and E7 encoded by HPV16 and 18,
are consistently expressed in HPV-associated Cervical cancer and are responsible for the
cervical cancer malignant progression. Targeting the E6/E7 proteins could be very helpful to
regress the CIN 1/2 and block the tumorigenesis.
By this research, we aim to establish the HPV16/18 E6/E7 peptide library which could induce
the strong anti-virus immune response and to vaccinate the CIN 1/2 patients with dendritic
cell vaccines loaded HPV 16/18 E6/E7 epitopes.
Including:
1. To create an effective HPV 16/18 E6/E7 antigen peptide library using NetMHCspan software
based on the MHC-I subtype of the Chinese population and screen E6/E7protein peptides
with high binding affinity to MHC molecules;
2. To develop HPV 16/18 E6/E7- pulsed DC vaccines and evaluate the safety and efficacy of
DC vaccines;
3. The patients are vaccinated with the HPV16/18 E6/E7- pulsed DC vaccines
4. To evaluate the safety and efficacy of DC vaccines loaded with HPV 16/18 E6/E7.
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