Cervical Dystonia, Primary Clinical Trial
Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary
neck muscle activity causing abnormal head postures and movements. It is the most frequent
form of adult focal dystonia. The distribution of dystonic muscles is unique for each
patient, explaining the variety of patterns encountered.
The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin
injections and/or specific retraining therapy programmes. Therefore, analyzing the
characteristics of abnormal head movements and identifying the dystonic muscles are the key
points of these treatments.
To a better understanding of the posture and movement disorders of head and neck, we wish to
establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy
subjects built from images obtained with the "Cone Beam " system. Then we will compare the
cervical posture and movements for each of ten CD patients matched in age and genre to the
computer model. Comparison with patients' images in the axial plane reconstructed by computer
with the 3-D computer model will lead to the description of various patterns of CD. Analysis
of the musculoskeletal disturbances in CD should be a help to improve the localization of
Botulinum Neurotoxin injection sites as well as retraining programmes.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03938363 -
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
|
N/A | |
| Terminated |
NCT02837185 -
Effects of Botulinum Toxin on Muscle and Brain Activity
|
N/A |