| Eligibility |
Inclusion Criteria:
- (IF Non-compliance with criterion "*" option, the visit WILL be rescheduled)
1. Chinese women aged 18-45 who can provide legal identification and had a sexual
life history;
2. The subject fully understands the study procedures, understands the risks and
benefits associated related this study, and voluntarily signs the informed
consent;
3. Subjects are able to read, understand and fill in application forms such as diary
CARDS and contact CARDS, and participate in regular follow-up visits according to
the study protocol;
4. *axillary's temperature <37.3? on the day of enrollment;
5. Subjects have not received any form of cervical cancer screening, or have been
received but the results are normal;
6. *0 days before the gynecological visit, no sex within 48 hours, no flushing or
vaginal cleaning within 72 hours, no use of vaginal drugs or preparations;
7. When the subjects were enrolled, the urine pregnancy test was negative
(sensitivity was 25mIU/ml ß-HCG), they were not in the lactation period, had no
family planning from Day 0 to 30 days after receiving the third dose of the
vaccine. Agree to continue to use effective contraception (including: oral
contraceptives, injectable or embedded contraceptives, sustained-release topical
contraceptives, hormone patches, intrauterine devices (IUDs), sterilization,
abstinence, condoms (men), diaphragms, cervical caps, etc.) from the day of
enrollment to 30 days after the third season of vaccination. Safe-period
contraception, in vitro ejaculation, and emergency contraception are unacceptable
methods of contraception.
Exclusion Criteria:
- (IF Non-compliance with criterion "*" option, the visit WILL be rescheduled)
1. Blood pressure (BP) before the first dose of vaccination was higher than normal
or increased (systolic BP =140mmHg and/or diastolic BP =90mmHg);
2. * Subjects had fever symptoms (axillary's temperature =37.3?) before the first
day of vaccination (within 24 hours before vaccination);
3. History of severe side effect to previous vaccinations or History of severe
allergies (e.g. Swelling of the mouth and throat, Dyspnea, Hypotension or Shock,
Severe urticaria) to components of study vaccine (e.g. Histidine, Polysorbate,
and Aluminium phosphate). History of severe allergies requiring medical
intervention, such as anaphylactic shock, anaphylactic laryngeal edema, allergic
purpura, thrombocytopenic purpura, local allergic necrosis reaction (Arthus
reaction), etc;
4. Subjects with compromised immune systemsor have been diagnosed with congenital or
acquired immune deficiency, HIV infection, lymphoma, leukemia, systemic lupus
erythematosus (SLE), rheumatoid arthritis, juvenile rheumatoid arthritis (JRA),
inflammatory bowel disease or Autoimmune thyroid disease (e.g.
Hyperthyroidism,Thyroiditis/Subacute thyroiditis,or Hypothyroidism), and other
Autoimmune diseases ;
5. Previous or current have epilepsy, seizures (except febrile seizures in children)
or convulsions, or mental diseases, with a family history of psychosis;
6. Absence of spleen or functional absence of spleen, and absence of spleen or
splenectomy in any case;
7. Previous or current have severe liver, kidney and cardiovascular diseases,
diabetic complications or malignant tumor;
8. Patients with thrombocytopenia or any coagulation disorders that may be
contraindications to intramuscular injection;
9. Immunosuppressant or immunopotentiator therapy within 1 month before the first
dose of vaccination, such as long-term use of systemic glucocorticoid therapy
(=2mg/kg/ day, for more than 2 weeks, such as prednisone or similar drugs;Topical
administration (such as ointment, eye drops, inhalant or nasal spray) exceeding
the recommended dosage in the directions or showing any signs of systemic
exposure) or planning to receive such treatment between the day of the first dose
and 30 days after the third dose of the vaccine;
10. Received any immunoglobulin or blood product within 3 months prior to the first
dose of vaccination, or plans to receive such product between the day of the
first dose and 30 days after the third dose of the vaccine;
11. * An acute illness or an acute episode of a chronic illness within 3 days prior
to vaccination, or use antipyretic, analgesic and antiallergic drugs (e.g.,
acetaminophen, ibuprofen, aspirin, loratadine, cetirizine, etc.);
12. Have participated in other gynecology-related clinical trials within 6 months,
and have used or plan to use other investigational or unregistered products
(drugs or vaccines) other than the vaccine in this study within 3 months;
13. * Received inactivated/recombinant/DNA vaccines (Non-attenuated vaccines) within
14 days prior to enrollment, or attenuated live vaccines within 28 days prior to
enrollment;
14. Have been vaccinated with commercially available HPV vaccine in the past or
planned to be vaccinated with commercially available HPV vaccine during the study
period;Or have participated in a clinical trial of the HPV vaccine and have
received a vaccine/placebo vaccination;
15. Subjects may be unable to comply with the study procedure, comply with the
agreement, or plan to permanently relocate from the region prior to completion of
the study, or may be permanently absent from the region during the scheduled
visit;
16. In the opinion of the investigators, the subjects had any other factors that made
them unsuitable to participate in the clinical trial, so that continued
participation in the study could not guarantee the maximum benefit of the
subjects;
17. * The first dose of vaccine was in pregnancy at the time of vaccination, or the
end of pregnancy had not exceeded 6 weeks;
18. * Subject is in the menstrual period;
19. Previous positive history of HPV;
20. Had a history of abnormal cervical cytology, including squamous intraepithelial
lesions (SIL) or not clear meaning of the atypical squamous cells (ASC - US),
except the atypical squamous cells - not highly squamous intraepithelial lesion
(ASC - H), atypical glandular epithelial cells, or those with cervical
intraepithelial neoplasia (CIN) and carcinoma in situ or abnormal cervical biopsy
results such as the history;
21. Previous history of vulvar intraepithelial neoplasia, vaginal intraepithelial
neoplasia, genital warts, vulvar cancer, vaginal cancer, cancer, etc. may be
caused by HPV infection;
22. Received total hysterectomy or pelvic radiotherapy;
23. Cervical insufficiency or abnormal cervical structure (judged by the results of
routine gynecological examination);
24. Previous sexual history (including syphilis, gonorrhea, chancre, venereal
lymphatic granuloma, granuloma inguinal) or had a history of condyloma;
25. Gynecological examination before the first dose of vaccination suspected genital
warts, or on the basis of clinical symptoms and signs suspected vulva, vagina or
cervical precancerous lesions and the possibility of cancer.
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