Cervical Cancer Clinical Trial
Official title:
Study on Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV
NCT number | NCT04974424 |
Other study ID # | S160 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2021 |
Est. completion date | December 1, 2023 |
Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.
Status | Recruiting |
Enrollment | 20000 |
Est. completion date | December 1, 2023 |
Est. primary completion date | December 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 25 Years to 75 Years |
Eligibility | Inclusion Criteria: - (1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis. - (2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality. Exclusion Criteria: - (1) suffering from other neoplastic diseases. - (2) pregnant women. - (3) those with a history of bone marrow transplantation. |
Country | Name | City | State |
---|---|---|---|
China | Tongji Hospital | Wuhan | Hubei |
Lead Sponsor | Collaborator |
---|---|
Huazhong University of Science and Technology | Obstetrics & Gynecology Hospital of Fudan University, Qilu Hospital of Shandong University, Shenzhen Second People's Hospital, Third Military Medical University, Women's Hospital School Of Medicine Zhejiang University, Wuhan Central Hospital, Xiangyang Central Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Significant loci of genetic variation | The impact of genetic variance on predisposition to cervical cancer | 2 |
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