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AN0025 and Pembrolizumab Combination in Advanced Solid Tumors

Cervical Cancer Clinical Trial

Official title:
An Open-Label Multicenter Phase Ib Study of AN0025 in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Clinical Trial Summary

This is an open-label, multicenter, phase Ib study to evaluate the safety and preliminary efficacy of AN0025 in combination with pembrolizumab in patients with locally advanced/metastatic tumors. It will include a dose-limiting toxicity observation phase followed by an expansion phase. All enrolled patients will be treated with AN0025 and Pembrolizumab until the patient experiences disease progression, unacceptable toxicity or withdraws consent, or for a maximum of 35 cycles (approximately 2 years). The dose of pembrolizumab will remain constant at 200 mg every 3 weeks (Q3W) for each dose level of AN0025 and in each cohort.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04432857
Study type Interventional
Source Adlai Nortye Biopharma Co., Ltd.
Contact
Status Active, not recruiting
Phase Phase 1
Start date August 20, 2020
Completion date January 30, 2025
View Details
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