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Clinical Trial Summary

Phase II multi-chort, adaptive two-stage, open label, nonrandomized study. The aim of our study is to evaluate the efficacy and safety of anti-PD-1 antibody SHR-1210(Camrelizumab) in combination with a small-molecule multikinase inhibitor Famitinib in subjects with advanced RCC/UC/CC/EC and recurrent OC. chort1: Renal Cell Carcinoma (RCC) chort2: Urothelial Carcinoma(UC) chort3: Ovarian Cancer (OC) chort4: Cervical Cancer (CC) chort5: Endometrial Cancer (EC)


Clinical Trial Description

Stage 1: Approximately 110 participants will be recruited, 22 participants per chort; Stage 2: Approximately 55 participants will be recruited, 11 participants per chort, if more than 7(including 7) patients reached ORR in every chort ; Approximately 155 participants will be recruited, 21 participants per chort, if 3 ≤ patients <7 patients reached ORR in every chort. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03827837
Study type Interventional
Source Jiangsu HengRui Medicine Co., Ltd.
Contact Quanren Wang, MD
Phone (+86) 021-50118402
Email wangquanren@hrglobe.cn
Status Recruiting
Phase Phase 2
Start date January 23, 2019
Completion date December 2022

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