Cervical Cancer Clinical Trial
Official title:
A Pilot Study of MR-Guided High Dose Rate Brachytherapy With MR Image Acquisition for Patients With Cervical Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Internal radiation
uses radioactive material placed directly into or near a tumor to kill tumor cells. Giving
radiation therapy in different ways may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving external-beam radiation together
with internal radiation works in treating patients with cervical cancer.
OBJECTIVES:
Primary
- Determine the feasibility of magnetic resonance-guided, endocavitary, high-dose rate
brachytherapy implants in patients with stage IB-IVB cervical cancer.
- Provide more reliable dose-volume estimations based on three-dimensional imaging-based
treatment planning in patients treated with this regimen.
Secondary
- Determine the toxic effects and treatment tolerance in patients treated with this
regimen.
- Correlate three-dimensional dose-volume histograms of organs at risk with treatment
toxicity in patients treated with this regimen.
- Determine the disease status, time and patterns of relapse, and survival of patients
treated with this regimen.
OUTLINE: Patients undergo external beam radiotherapy 4-5 days a week for up to 7 weeks.
Patients also undergo MRI-guided high-dose brachytherapy comprising one brachytherapy
implant a week for 3-6 implants. Brachytherapy may be administered during or after external
beam radiotherapy.
After completion of study treatment, patients are followed periodically for 5 years.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
;
Primary Purpose: Treatment
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