Cervical Cancer Clinical Trial
Official title:
Phase II Evaluation of Oxaliplatin in Persistent or Recurrent Squamous Cell Carcinoma of the Cervix
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of oxaliplatin in treating patients who
have recurrent or refractory cervical cancer.
OBJECTIVES: I. Determine the antitumor activity of oxaliplatin by measuring response rate in
patients with recurrent or refractory squamous cell carcinoma of the cervix who have failed
on higher priority treatment protocols. II. Determine the nature and degree of toxicity of
this drug in this patient population.
OUTLINE: Patients receive oxaliplatin IV over 2 hours. Treatment continues every 21 days for
a maximum of 9 courses in the absence of unacceptable toxicity or disease progression.
Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 22-60 patients will be accrued for this study within 12-14
months.
;
Primary Purpose: Treatment
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