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A Clinical Study on the Treatment of Cerebral Small Vascular Disease — MAP-CSVD  

Cerebral Small Vessel Diseases Clinical Trial

Official title:
A Multi-center, Randomized, Double-Blind, Placebo-Controlled Study of Dl-3-Butylphthalide on the Treatment of Small Cerebral Vessel Disease

Clinical Trial Summary

This study is designed to evaluate the safety and efficacy of butylphthalide (NBP) in the treatment of cerebral small vessel disease through a multicenter, randomized,double-blind, placebo-controlled study. Butylphthalide Soft Capsule and placebo were prescribed to the experimental group and the control group for a period of 24-months, respectively. After that, the experimental group and the control group were given Butylphthalide Soft Capsule for 6 months.

Clinical Trial Description

Butylphthalide can protect mitochondrial function and inhibit neuronal apoptosis by significantly increasing the activity of mitochondrial ATP complex enzyme and mitochondrial respiratory chain complex enzyme IV, improving the fluidity of mitochondrial membrane and maintaining mitochondrial membrane potential. Butylphthalide can reconstruct microcirculation and protect mitochondria, which can protect neurovascular units in an all-round way. Findings from previous studies have shown that butylphthalide can improve the ability of daily living of patients with ischemic cerebrovascular disease and can enhance cognitive function of patients diagnosed as subcortical vascular cognitive impairment no dementia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04078204
Study type Interventional
Source Peking Union Medical College Hospital
Contact Ruixin Pan
Phone 173 3112 8346
Email ly02034478@163.com
Status Recruiting
Phase N/A
Start date April 25, 2018
Completion date June 2022
View Details
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