Cerebral Small Vessel Diseases Clinical Trial
Official title:
The Effect of Hyperbaric Oxygen on the Functional Connectivity of Resting State Neural Networks in Patients With Cerebral Small Vessel Disease
Verified date | October 2017 |
Source | St. Luke's Hospital, Chesterfield, Missouri |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.
Status | Terminated |
Enrollment | 6 |
Est. completion date | October 25, 2017 |
Est. primary completion date | October 25, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years to 90 Years |
Eligibility |
Inclusion Criteria: - White Matter Hyperintensities on MRI - 2 or more neurological symptoms or impairments e.g. gait disturbances, disequilibrium, cognitive decline, dysmetria, hyper-rflexia Exclusion Criteria: - Contraindication to hyperbaric oxygen treatment e.g. pulmonary emphysema, seizure disorder - major eustachian tube dysfunction - stroke with previous 6 months - extreme cognitive impairment - major depression - history of migraine, electroshock therapy, brain irradiation, brain tumor, head trauma - other uncontrolled co-morbidities, e.g. diabetes, renal or hepatic dysfunction, hypertension, thyroid disorders, carotid artery stenosis (>70%) |
Country | Name | City | State |
---|---|---|---|
United States | St. Luke's hospital | Chesterfield | Missouri |
United States | Mallinckrodt Institute of Radiology/Washington University Medical School | Saint Louis | Missouri |
United States | St. Luke's Hospital | Saint Louis | Missouri |
Lead Sponsor | Collaborator |
---|---|
St. Luke's Hospital, Chesterfield, Missouri | Washington University School of Medicine |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in average functional connectivity (fc) within the Default Mode Network and the Dorsal Attention Network will be obtained by resting state network (rsn) functional connectivity (rsnfc) MRI. | Functional connectivity MRI of resting state neural networks. | Change in baseline rsnfc before and 4 weeks after hyperbaric oxygen |
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