Cerebral Palsy Clinical Trial
Official title:
In Vivo Assessment of Quadriceps Muscle Plasticity in Children With Cerebral Palsy
Verified date | May 2018 |
Source | Medical University of South Carolina |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Our primary aim is to determine whether and how muscle architecture of the quadriceps muscles in cerebral palsy (CP) adapts to two separate training programs: traditional strength training (ST) vs. velocity-enhanced training (VT). For the ST group, we hypothesize that muscle size will increase in conjunction with strength. For the VT group, in addition to the above, we hypothesize that fiber length will increase with measures of muscle power. We also hypothesize that walking velocity will improve in both groups but that knee motion and step length will improve only with VT.
Status | Completed |
Enrollment | 16 |
Est. completion date | December 13, 2010 |
Est. primary completion date | December 13, 2010 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 7 Years to 17 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of cerebral palsy - Gross motor function classification system levels I, II, or III - Ages 7 to 17 Exclusion Criteria: - Orthopedic or neurosurgery within the past year - Botulinum toxin injections within the 4 months prior to the study |
Country | Name | City | State |
---|---|---|---|
United States | Neuromuscular Assessment Laboratory | Charleston | South Carolina |
Lead Sponsor | Collaborator |
---|---|
Medical University of South Carolina |
United States,
Damiano DL, Vaughan CL, Abel MF. Muscle response to heavy resistance exercise in children with spastic cerebral palsy. Dev Med Child Neurol. 1995 Aug;37(8):731-9. — View Citation
Mohagheghi AA, Khan T, Meadows TH, Giannikas K, Baltzopoulos V, Maganaris CN. Differences in gastrocnemius muscle architecture between the paretic and non-paretic legs in children with hemiplegic cerebral palsy. Clin Biomech (Bristol, Avon). 2007 Jul;22(6):718-24. Epub 2007 May 1. — View Citation
Moreau NG, Li L, Geaghan JP, Damiano DL. Contributors to fatigue resistance of the hamstrings and quadriceps in cerebral palsy. Clin Biomech (Bristol, Avon). 2009 May;24(4):355-60. doi: 10.1016/j.clinbiomech.2009.01.012. Epub 2009 Mar 5. — View Citation
Moreau NG, Teefey SA, Damiano DL. In vivo muscle architecture and size of the rectus femoris and vastus lateralis in children and adolescents with cerebral palsy. Dev Med Child Neurol. 2009 Oct;51(10):800-6. doi: 10.1111/j.1469-8749.2009.03307.x. Epub 2009 Apr 21. — View Citation
Shortland AP, Harris CA, Gough M, Robinson RO. Architecture of the medial gastrocnemius in children with spastic diplegia. Dev Med Child Neurol. 2002 Mar;44(3):158-63. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle thickness | before and after intervention | ||
Secondary | Fascicle length | before and after intervention | ||
Secondary | Muscle strength (peak torque) | before and after intervention | ||
Secondary | Muscle power | before and after intervention |
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