Cerebral Embolism Clinical Trial
— COMET-AKIOfficial title:
Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy.
NCT number | NCT02621749 |
Other study ID # | 199/2015 |
Secondary ID | |
Status | Terminated |
Phase | N/A |
First received | |
Last updated | |
Start date | January 2017 |
Est. completion date | November 6, 2022 |
Verified date | November 2022 |
Source | University Hospital Inselspital, Berne |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.
Status | Terminated |
Enrollment | 66 |
Est. completion date | November 6, 2022 |
Est. primary completion date | November 6, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - > 18 yrs. - Signed IC Exclusion Criteria: - Heart disease (PFO, ASD, VSD, severe valvular disease) - Atrial fibrillation - Cerebrovascular pathology - Missing temporal bone window - Allergy to plastic contained in the investigative device (transcranial Doppler) - Chronic kidney disease - Pregnancy - Participation in another study |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Bern | Bern |
Lead Sponsor | Collaborator |
---|---|
University Hospital Inselspital, Berne |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound | During hemodialysis therapy |
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