A Study of AMDX-2011P in Participants With CAA

Status Recruiting

Clinical Trial Summary

The purpose of this study is to assess safety, tolerability, plasma pharmacokinetics and biologic activity of a single intravenous dose of AMDX-2011P in participants with cerebral amyloid angiopathy (CAA).

Clinical Trial Description

This open-label, masked endpoint assessment study will evaluate the safety, tolerability, plasma pharmacokinetics (PK) and biological activity of an intravenous (IV) dose of AMDX-2011P in participants with CAA. Assessments of retinal images will be conducted by central masked assessors. Participants will be admitted to the study site where eye examination and retinal imaging will be conducted before administration of the study drug. AMDX-2011P will be administered through a single IV bolus injection followed by safety assessments, retinal imaging and PK blood collection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05709314
Study type	Interventional
Source	Amydis Inc.
Contact	Joyce Simpauco, MPH
Phone	858-254-7435
Email	joyce@amydis.com
Status	Recruiting
Phase	Phase 2
Start date	April 2024
Completion date	December 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05486897` - Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy
Recruiting	`NCT03969732` - Multimodal Biomarkers for Diagnosis and Prognosis in CAA	Phase 3
Completed	`NCT03542656` - Application of Amyloid PET in Cerebral Amyloid Angiopathy	Phase 3
Recruiting	`NCT04604587` - MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA	Phase 3
Completed	`NCT05565144` - Brain Hemorrhage and Functional Outcome in Stroke Patients With CAA Features on Pre-thrombolysis MRI Treated With Intravenous Thrombolysis (Thrombolysis in CAA) ( Thromb in CAA )
Active, not recruiting	`NCT03464344` - Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.	N/A
Completed	`NCT03824197` - Auburn University Research on Olive Oil for Alzheimer's Disease (AU-ROOAD)	N/A
Recruiting	`NCT06393712` - A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy	Phase 2
Active, not recruiting	`NCT01856699` - Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy	N/A
Recruiting	`NCT06128824` - High Frequency Imaging in Cerebral Amyloid Angiopathy
Completed	`NCT01821118` - Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy	Phase 2
Not yet recruiting	`NCT06421532` - Stimulating Amyloid Clearance in Cerebral Amyloid Angiopathy	Phase 2
Completed	`NCT05394636` - Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Recruiting	`NCT04204642` - SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA)
Recruiting	`NCT05207475` - Safety and Efficacy of Remote Ischemic Conditioning on Cerebral Amyloid Angiopathy. (RIC-CAA)	N/A
Recruiting	`NCT04757597` - Remote Ischemic Conditioning for Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage	N/A
Not yet recruiting	`NCT02361411` - Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy	N/A
Not yet recruiting	`NCT04654026` - the Safety and Efficacy of Antiplatelet Therapy in Patients of CAA
Completed	`NCT05082194` - Balance Eyesight and Muscle Tension in the Cervical Spine in Cerebral Amyloid Angiopathy
Completed	`NCT04825808` - Detailed Clinical and MRI Characteristics in Primary Non-traumatic Convexity Subarachnoid Haemorrhage Elderly Patients.