Cerebellar Hypoplasia Clinical Trial
Official title:
Perinatal and Long-term Outcome of Newborns With an Isolated Small Transverse Cerebellar Diameter
The decreased cerebellar biometry during second and third trimester ultrasound examination is
the main parameter to diagnoses cerebellar and pontocerebellar hypoplasia. Investigators
already described that a transverse cerebellar diameter (TCD) below the 5th centile at second
or third trimester scan is related to a high rate of fetal malformations, severe intrauterine
restriction in growth, chromosomal anomalies and genetic disorders, therefore when facing a
TCD below the 5th centile, patients should be referred for oriented sonogram, fetal MRI
(Magnetic resonance imaging) and fetal karyotyping.
However, prenatal counseling in case of an isolated decreased cerebellar biometry remains
challenging since there are no data in the literature regarding the neurodevelopmental
outcome of these newborns. The aim of this work is to evaluate the neurodevelopmental outcome
of newborns with a prenatal isolated decreased cerebellar biometry, in order to improve
prenatal counseling.
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