Central Venous Pressure Monitoring and Prognosis of High-risk Operating Patients

Central Venous Pressure Clinical Trial

Official title:

Central Venous Pressure Monitoring is Associated With Improved Prognosis of High-risk Operating Patients During Perioperative Period

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04596332
• Other study ID #: K2018-09-006
• Status: Completed
• Start date: February 1, 2014
• Est. completion date: March 30, 2020

Study information

• Verified date: October 2020
• Source: Fujian Provincial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

While central venous pressure measurement is used to guide fluid management in high risk surgical patients during perioperative period, the relationship between the value of central venous pressure and organ dysfunction and prognosis of high-risk operating patients is unknow. In this study, we conducted a retrospective study of the relationship between the initial levels of CVP with organ dysfunction, the severity of illness, the length of ICU stay, and prognosis of critically ill patients.

Description:

Although less than 15% of high-risk patients (elderly or with limited cardiopulmonary reserves) undergo surgery, these patients account for 80% of hospital deaths. The requirements for hemodynamic monitoring to critical patients during perioperative period reach are of maximal importance, for two major reasons: (i) absolute or relative volume deficiency often occurs in postoperative patients due to preoperative fasting, intraoperative bleeding and non-dominant fluid loss caused by vasodilation and fluid redistribution caused by anesthesia; (ii) insufficient fluid replacement may lead to increased postoperative organ complications and poor wound healing. Adequate and goal-oriented hemodynamic monitoring combined with early and appropriate treatment can improve the prognosis of high-risk surgical patients.

Central venous pressure is a localized parameter of the superior vena cava or the right atrium and is closely related to the right ventricular end-diastolic pressure. With volume overload, CVP levels may be abnormally elevated. Maintaining central venous pressure as low as possible is conducive to the recovery of internal organs during haemodynamic treatment, especially for the kidney, intestine, and brain, etc. However, elevated central venous pressure (CVP) occurs frequently in critical care settings, including postoperative critical patients. In this study, we conducted a retrospective study of the relationship between the initial levels of CVP with organ dysfunction, the severity of illness, the length of ICU stay, and prognosis of critically ill patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 196
• Est. completion date: March 30, 2020
• Est. primary completion date: March 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Age =18 years.? All patients undergoing surgery and admitted to our intensive care unit (ICU) directly after surgery were enrolled into the respective study.? They stayed in the ICU more than 48 hours with central venous pressure monitored for more than 48 hours.

Exclusion Criteria:

• Patients who were in pregnancy. ?Older than 80 years. ?Underwent cardiac surgery or had chronic kidney disease.

Related Conditions & MeSH terms

• Central Venous Pressure

Intervention

Other:
• no intervention measures
Because this study was a retrospective study, no intervention measures were implemented for the patients enrolled.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fujian Provincial Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Primary Outcome	28-day mortality, length of stay in intensive care unit and hospitalization, surgical complications	28-day
Secondary	Secondary Outcome	Comparison of perioperative fluid management in each group	1-day