Central Serous Chorioretinopathy Clinical Trial
Official title:
The Changes of Retinal and Choroidal Capillaries After Half-dose Photodynamic Therapy Measured by Angio- OCT in Eyes With Central Serous Chorioretinopathy
To determine changes in retinal and choroidal capillaries with optical coherence tomographic angiography (OCTA) after half-dose photodynamic therapy (hd-PDT) in eyes with central serous chorioretinopathy (CSC).
PDT was hypothesized to have a primary effect on the choroidal capillaries, and a number of
studies have reported choriocapillary damage and choroidal vascular remodeling after PDT.
More recently, although OCTA related CSC research has been conducted, no quantitative report
has thoroughly investigated the microstructural changes in the superficial, deep retinal and
choroidal capillaries after hd-PDT. The purpose of the present study is to determine the
changes in the retinal and choroidal capillaries quantitatively with OCTA after hd-PDT in
eyes with CSC.
This is a prospective observational study of patients undergoing hd-PDT for CSC with active
leakage in retinal pigment epithelium (RPE) and followed for 3 months. Fundus fluorescein
angiography (FFA) and indocyanine green angiography (ICGA) were performed at baseline; best
corrected visual acuity (BCVA), fundus photography, optical coherence tomography angiography
(OCTA) with the split-spectrum amplitude-decorrelation angiography algorithm (XR Optovue,
Fremont, CA, USA) and spectral domain OCT (SD-OCT) were performed at baseline and each
follow-up visit after hd-PDT.
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