Central Nervous System Embryonal Neoplasm Clinical Trial
Official title:
Gene Expression Profiling of Infant Embryonal Central Nervous System Tumors by Microarray Gene Chip Analysis: Angiogenesis, Invasion and Metastasis
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the
development of some types of cancer.
PURPOSE: Genetic study to learn more about genes involved in the development of central
nervous system tumors in young children.
OBJECTIVES:
- Identify known genes that have significantly different levels of expression, using
microarray gene chip analysis, in infants with newly diagnosed metastatic vs
non-metastatic embryonal central nervous system tumors.
- Determine the protein expression of genes identified by microarray analysis that are
involved in cellular functions that regulate angiogenesis, invasion, or metastasis in
this patient population.
- Determine the quantity of gene expression of the confirmed translationally expressed
genes using semi-quantitative polymerase chain reaction.
OUTLINE: This is a multicenter study.
Tumor samples are analyzed using microarray gene chip analysis. Differentially expressed
genes are evaluated for protein expression by standard immunohistochemistry and/or Western
blot analysis, and gene expression is further quantified by semi-quantitative polymerase
chain reaction.
PROJECTED ACCRUAL: Approximately 80-100 patients (20-25 with metastatic disease and 60-75
with non-metastatic disease) will be accrued for this study within 4-5 years.
;
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT00983398 -
Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
|
Phase 1/Phase 2 |