Clinical Trials Logo

Clinical Trial Summary

In this trial, we will treat newly diagnosed PCNSL with temozolomide, nedaplatin, vincristine (TNV) as the replacement of high-dose methotrexate to combine with concurrent chemoradiotherapy. Our objective was to assess our treatment strategies' availability based on response rates, progression-free survival (PFS), median PFS, and toxicity.


Clinical Trial Description

The best reported outcomes of PCNSL treatment are high-dose methotrexate-based chemotherapy combined with whole-brain radiation therapy (WBRT). Despite aggressive therapy, however, nearly 50% of patients will relapse within 24 months of diagnosis. Furthermore, the application of high-dose methotrexate-based regimen is complex, needing be hydrated, alkalified and detoxified, and treatment-related toxicity mortality is severe[3,4]. In an attempt to improve upon these poor results and reduce treatment-related side effects, we will treat about 15-20 PCNSL patients with temozolomide concurrent chemoradiotherapy at the outset and then adjuvant chemotherapy for 6 cycles with temozolomide, nedaplatin, vincristine, as part of front-line therapy. Our objective is to assess our treatment strategies' availability based on response rates, progression-free survival (PFS), median PFS, and toxicity. ;


Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01735747
Study type Interventional
Source Shandong Cancer Hospital and Institute
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 2008
Completion date November 2013

See also
  Status Clinical Trial Phase
Completed NCT00876993 - Study of Irinotecan and Bevacizumab With Temozolomide in Refractory/Relapsed Central Nervous System (CNS) Tumors Phase 1
Completed NCT00003935 - Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma Phase 1
Terminated NCT00107471 - Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem Glioma Phase 1/Phase 2
Completed NCT00003573 - Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma Phase 2
Recruiting NCT05235074 - OH2 Oncolytic Viral Therapy in Central Nervous System Tumors Phase 1/Phase 2
Suspended NCT05308407 - POWER UP: Participating Online While Exercising to Recover Using Play N/A
Terminated NCT00477503 - Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA Phase 1
Active, not recruiting NCT01985451 - Pemetrexed and Temozolomide in Treating Patients With Relapsed Primary Central Nervous System Lymphoma (PCNSL) Phase 2
Withdrawn NCT00109798 - Temozolomide and Topotecan in Treating Patients With Primary CNS Lymphoma N/A
Completed NCT00003141 - Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Phase 1
Completed NCT00003203 - Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal Tumors Phase 2
Completed NCT02462629 - Study of BLZ-100 in Pediatric Subjects With CNS Tumors Phase 1
Recruiting NCT00607984 - Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors N/A
Completed NCT00899834 - DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma N/A
Completed NCT00066248 - Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Phase 2
Completed NCT00187226 - A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects Phase 2
Completed NCT02793466 - Durvalumab in Pediatric and Adolescent Patients Phase 1
Withdrawn NCT01052363 - OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas Phase 1
Completed NCT00047320 - Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Phase 2
Completed NCT00945828 - Assessing the Effectiveness of Individual Education Plans for Childhood Cancer Survivors N/A