Cataract Clinical Trial
Official title:
The Effect of Cataract on Photoentrainment of the Circadian Rhythm in Humans
Cataract is globally the most common cause of blindness and in Denmark the operation with -
50.000 treatments per year - is the most common eye operation. The cause of cataract is
growth and denaturation of the lens proteins. This leads to an increased absorption of blue
light and increased light scatter. This may affect newly discovered cells in the retina that
are involved in the regulation of the circadian rhythm. When the internal circadian rhythm
is not synchronized with the external day and night a phase-shift occurs. Most people know
of this discomfort as jet-lag, but the consequences may be much more severe such as heighten
risk of cancer and cardiovascular disease.
The goal of this project is to study how the circadian regulating cells of the retina is
affected by cataract and by the operation. Cataract patients are studied before and after
the operation with questionnaires, hormone and activity measurements and with a specialized
pupil measurement that measures the indirect response of the circadian regulating cells to
blue light.
Results from this study aim to shed light on the regulatory mechanisms of the eye on the
circadian rhythm and how these are affected by cataract. Furthermore, choice of intraocular
lens is evaluated. This may have impact on clinical practise especially with regard to
choice of intraocular lens and widened indications for cataract surgery.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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