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Cat Allergy clinical trials

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NCT ID: NCT01033344 Completed - Cat Allergy Clinical Trials

Cat-PAD Exposure Chamber Study

Start date: January 2010
Phase: Phase 2
Study type: Interventional

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. Cat-PAD is a novel, synthetic, allergen-derived peptide desensitising vaccine, currently being developed for the treatment of cat allergy. This study will look at the efficacy, safety and tolerability of two doses of Cat-PAD in cat allergic subjects following challenge to cat allergen in an EEC.

NCT ID: NCT01003301 Completed - Cat Allergy Clinical Trials

The Effects of Omalizumab (Anti-IgE) on the Late-phase Response to Nasal Allergen Challenge

Start date: October 2009
Phase: Phase 2
Study type: Interventional

This research is being done to study the effects of the drug omalizumab (Xolair) in people with cat allergies. The investigators will use omalizumab to study changes in the cells in the nose, cells in the blood and cells in the skin that cause allergies. The investigators will compare the changes in the nose to changes in the skin and blood cells. Objective: To test the hypothesis that treatment with omalizumab will decrease the nasal allergen challenge late-phase eosinophil count in nasal brushings at the time when blood basophils have become hypo-responsive to in vitro allergen exposure.

NCT ID: NCT00987909 Completed - Cat Allergy Clinical Trials

Exposure Chamber Trial With Cat Immunotherapy

Start date: September 2009
Phase: Phase 2
Study type: Interventional

The main purpose of this trial is to investigate if any of three different doses of cat hair immunotherapy is safe for treatment of cat allergic patients.

NCT ID: NCT00867906 Completed - Cat Allergy Clinical Trials

Safety of Cat-PAD to Treat Cat Allergy in Cat Allergic Subjects With Controlled Asthma

Start date: March 2009
Phase: Phase 2
Study type: Interventional

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. Cat-PAD is a novel, synthetic, allergen-derived peptide desensitising vaccine, currently being developed for the treatment of cat allergy. This study will evaluate the safety and tolerability of multiple doses of Cat-PAD in controlled asthmatics treated with either inhaled salbutamol, inhaled corticosteroids or inhaled corticosteroids with a LABA and to explore the efficacy of Cat-PAD in these subjects using the Late Phase Skin Response, Early Phase Skin Response, and Conjunctival Provocation Test.

NCT ID: NCT00729508 Completed - Cat Allergy Clinical Trials

Effectiveness of Cat-PAD to Treat Cat Allergy in Cat Allergic Subjects

Start date: August 2008
Phase: Phase 2
Study type: Interventional

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. Cat-PAD is a novel, synthetic, allergen-derived peptide desensitising vaccine, currently being developed for the treatment of cat allergy. This study will investigate the efficacy of 4 treatment regimens of Cat-PAD in cat allergic subjects following challenge to cat allergen in an environmental exposure chamber (EEC).

NCT ID: NCT00685711 Completed - Cat Allergy Clinical Trials

Safety of Cat-PAD in Cat Allergic Subjects

Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

Cat allergy is an increasingly prevalent condition, affecting 10-15% of patients with allergic rhinoconjunctivitis and/or asthma. Cat-PAD is a novel, synthetic, allergen-derived peptide desensitising vaccine, currently being developed for the treatment of cat allergy. This study will investigate the safety of Cat-PAD administered as increasing single doses.