Carotid Plaque Clinical Trial
Official title:
Study of microRNAs in the Evolution of Carotid Plaque. Physiopathological and Therapeutic Interest
Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the most important causes of morbidity and mortality in the Western world
Carotid stenosis of atherosclerotic origin may be responsible for stroke, which is one of the
most important causes of morbidity and mortality in the Western world. The constitution of
the atheroma plaque is linked to the deregulation of several biological phenomena, including
angiogenesis, adipogenesis, inflammatory response, lipid metabolism and oxidative stress. In
addition to its anatomical and physiological characteristics, the notion of plate stability
is of paramount importance for clinical implications. This stability depends largely on the
biological composition of the plate. A vulnerable or unstable plaque often has a large lipid
body consisting of foam cells (macrophages laden with oxidized LDL) with a thin fibrous
screed consisting of smooth muscle cells (CML), collagen fibers and extracellular matrix.
This plaque is also made up of numerous inflammatory cells including macrophages, rich
vascularization and intraplate hemorrhage. Although the cell composition of the unstable
plate is still relatively established, its molecular analysis remains little known.
The benefit of carotid surgery in asymptomatic patients with stenosis greater than 70% is
increasingly controversial given the moderate risk of spontaneous stroke under optimal
medical treatment. This annual average risk is less than 5%. Thus, the discovery of an
original and innovative biomarker, predictive of plate rupture, would define the patients
most at risk, who benefit most from this surgery.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05764772 -
CT Evaluation of Carotid Plaque Components
|
||
| Terminated |
NCT01132768 -
The Confirmatory Olmesartan Plaque Regression Study
|
Phase 4 | |
| Completed |
NCT03665818 -
The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic Stroke
|
N/A | |
| Enrolling by invitation |
NCT03308773 -
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
|
||
| Active, not recruiting |
NCT05843487 -
Association Between Carotid Plaque Length and Cardiovascular Outcomes
|
||
| Completed |
NCT06187532 -
Carotid Plaque-Burden Scale and Outcomes. A Real Life Study
|