Cardiovascular System Clinical Trial
Official title:
Vascular Adaptations to Single-Sprint Training
The long-term objective of this research line is to identify and implement an effective and feasible intervention capable of preventing and/or reducing the burden of cardiometabolic and obesity-related diseases that affect Mississippians and others. The pursuit of this long-term objective will begin with achieving the specific aims proposed in this pilot project, which are to determine the effect of single sprint training for improving (1) systemic macro-vascular function, (2) local and systemic micro-vascular function, and (3) cardiorespiratory fitness. These aims will be achieved using a randomized controlled trial whereby 40 males and females will be randomized into an intervention group (n=20) or time-matched negative control group (n=20). The intervention group will perform a single maximal effort sprint on a cycle ergometer for twenty seconds 3 days/week for 4 weeks and the control group will be asked to maintain pre-intervention habits/behavior over 4 weeks. All outcome measures are non-invasive, and will be assessed pre-, mid-, and post-intervention, with the exception of cardiorespiratory fitness, which will be measured pre- and post-. To achieve aim 1, brachial artery flow-mediated dilation via ultrasonography and systolic and diastolic blood pressure via automated oscillometry will be measured on the arm. To achieve aim 2, post-occlusive reactive hyperemia via near-infrared spectroscopy and reactive hyperemia via ultrasound will be measured in the arm and leg, respectively. To achieve aim 3, pulmonary gas exchange will be measured during a graded exercise test on a cycle ergometer. All outcomes will be compared across time between conditions and sex with a three-way Bayesian Repeated Measures ANOVA using pre-values as covariates and an uninformed prior. 95% credible intervals will also be calculated to power future investigations using this intervention. If the intervention is found effective, future studies will be conducted to determine the efficacy of the intervention in larger groups and more clinical populations, and to determine the mechanisms mediating the adaptations. If ineffective, the knowledge gained will be used to develop future interventions.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03697499 -
Effects of Fish Oil in Alleviating Health Hazards Associated With Ozone Exposure
|
N/A | |
Active, not recruiting |
NCT04153539 -
Acute Health Effects of Traffic-Related Air Pollution Exposure
|
N/A | |
Completed |
NCT04579497 -
Temperature-dependent Changes in Cardiovascular Parameters During Warm Water Footbaths in Healthy Women
|
N/A | |
Active, not recruiting |
NCT05575752 -
Acute Health Effects of High Temperature Exposure
|
N/A | |
Completed |
NCT02977390 -
Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM
|
N/A | |
Not yet recruiting |
NCT06076629 -
Acute Health Effects of Low Temperature Exposure
|
N/A | |
Completed |
NCT05866848 -
Effects of Caffeine on Cerebral Blood Flow
|
N/A | |
Completed |
NCT05289817 -
Effects of Transcutaneous Electrical Stimulation on the Autonomous Nerve System in Healthy Young People
|
N/A | |
Completed |
NCT04209738 -
Changes in Cardiovascular and Sleep Quality Parameters Under Eurythmy Therapy and Tai Chi in Comparison to Standard Care - A Substudy of the ENTAiER Trial
|
||
Completed |
NCT02979327 -
Cardiovascular Effects of Adderall in Healthy Adults.
|
Early Phase 1 | |
Completed |
NCT01940822 -
Cardiovascular Effects of Energy Drinks in Healthy Adults
|
N/A | |
Completed |
NCT03395977 -
Uric Acid Effects on Endothelium and Oxydative Stress
|
N/A | |
Completed |
NCT03810118 -
Fluid Challenge Infusion and Response
|
N/A |