Cardiovascular Abnormalities Clinical Trial
Official title:
Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders
Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 18 Years to 45 Years |
Eligibility | Inclusion Criteria: - Anabolic steroid use in the past or actually; - Participation at least one bodybuilding competition; Exclusion Criteria: - Previous history of acute myocardial infarction and/or stroke; - Allergy or intolerance to nitrate, gluten, or milk; - Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists). |
Country | Name | City | State |
---|---|---|---|
Brazil | EEFERP - USP / Laboratório de Fisiologia do Exercício e Metabolismo | Ribeirão Preto | São Paulo |
Lead Sponsor | Collaborator |
---|---|
University of Sao Paulo |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Macrovascular function (Flow mediated dilatation%) | up to 2 years | ||
Secondary | Plasmatic concentrations of nitrate and nitrite (mmol/L) | up to 2 years | ||
Secondary | Values of systolic and diastolic blood pressure (mmHg) | up to 2 years | ||
Secondary | Values of heart rate variability (ms) | up to 2 years | ||
Secondary | Values of heart rate (beats per minute) | up to 2 years | ||
Secondary | Values of hand grip strength (kgF) | up to 2 years |
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