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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT04191265
Other study ID # cardiotoxicity of ALP cases
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date December 5, 2019
Est. completion date June 5, 2020

Study information

Verified date May 2020
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas. The heart,lungs, liver are the main targets in acute Aluminum phosphide (AlP) poisoning. Most deaths occur due to cardiovascular toxicity.


Description:

Aluminium phosphide is a potent respiratory chain enzyme inhibitor. Its most important effect is the inhibition of cytochrome c oxidase. The inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms. It stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (MAD), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione . Oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 60
Est. completion date June 5, 2020
Est. primary completion date June 5, 2020
Accepts healthy volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: ALP poisoned cases

- admitted with free ECG

Exclusion Criteria:

concomitant ingesion of other drugs or toxins

-

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
serum tropinin, serum CKmb
early detection of myocardial injury, allowing application of acute cardiac shock and cardiogenic shock

Locations

Country Name City State
Egypt Doaa Assiut

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury 6 months
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