The Critical Threshold of Pulse Oximetry Plethysmographic Waveform Parameters in High Quality CPR

Cardiopulmonary Resuscitation Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03754946
• Other study ID #: 201502019
• Status: Recruiting
• Start date: September 1, 2015
• Est. completion date: December 31, 2018

Study information

• Verified date: November 2018
• Source: Peking Union Medical College Hospital
• Contact: Xuezhong Yu, MD
• Phone: +86 010 69159142
• Email: yxzpumch[@]126.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to analyze the relationship of the area under the curve (AUC) and/or the amplitude (Amp) of pulse oximetry plethysmographic waveform (POP) with partial pressure of end-tidal carbon dioxide (PETCO2) which could be used to reflect its quality in cardiopulmonary resuscitation (CPR), and then to determine the critical threshold of POP parameters in high quality CPR.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: December 31, 2018
• Est. primary completion date: June 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Cardiac arrested

• The time from cardiac arrest to receiving basic life support is less than 10 minutes

• Get advanced life support (endotracheal intubation and PETCO2 monitoring)

Exclusion Criteria:

• Defuse CPR

• chronic obstructive pulmonary disease (COPD) with type II respiratory failure

• Terminal malignant tumors or terminal stage of other diseases

• Rib fracture

• Cardiac arrest caused by hemorrhagic shock pulmonary embolism and cardiac tamponade

• Sever anemia(HGB<7g/dl)

• Untreated tension pneumothorax

• Tinea unguium, dyeing Fingernails and other factors affect the monitor of Pulse Oximetry Plethysmographic Waveform such vasculitis and Raynaud's phenomenon

Related Conditions & MeSH terms

• Cardiopulmonary Resuscitation

Locations

Country	Name	City	State
China	Peking Union Medical College Hospital	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking Union Medical College Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the cut-off value of POP parameters in High Quality CPR	Describe the the cut-off value of POP parameters in High Quality CPR. Receiver operating curve analysis was performed to evaluate the accuracy in predicting return of spontaneous circulation (ROSC).	one year
Primary	Compare different predictors	Area under curve (AUC) between potential predictors was compared by using a nonparametric test, and the optimal cutoff point was determined by estimating the Youden's index.	one year