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Plasma Gabapentin Concentration During and Following Cardiac Bypass

Cardiopulmonary Bypass Clinical Trial

Official title:
Preemptive Gabapentin Administration and Perioperative Plasma Concentrations With Cardiac Bypass

Clinical Trial Summary

This open label investigation is to determine whether cardiopulmonary bypass affects plasma gabapentin concentration after preoperative administration in the setting of cardiac bypass surgery. Following signed informed consent, 16 patients scheduled for cardiac bypass surgery will be given gabapentin (600mg, oral) 1 hour prior to surgery, 1 hour following extubation and then every 8 hours for a total of 4 doses. Plasma gabapentin levels will be measured prior to induction, prior to bypass, 10 min into the bypass procedure, 10 minutes before separation from bypass, 30 minutes following bypass and then before and 2 hours following each of the next 3 doses of gabapentin. Pain scores, sedation scores, side effects and morphine equivalents will be documented for one day following surgery.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01022736
Study type Interventional
Source Queen's University
Contact
Status Completed
Phase Phase 4
Start date May 2007
Completion date September 2007
View Details
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