Ultrafiltration on Coagulation Performance in Cardiac Surgery

Status Completed

Clinical Trial Summary

In cardiac surgery patients with CPB-induced dilutional coagulopathy, ultrafiltration (UF) was applied to reduce free water and concentrate all blood components before the weaning from CPB. The impact of UF on the clot strength is determined by analyzing the changes of maximal clot formation in EXTEM assay (MCF-EXTEM) in the ROTEM test in patients who underwent elective cardiac valve surgery in KUMC.

Clinical Trial Description

In cardiac surgery patients, ultrafiltration (UF) was applied to reduce free water and concentrate all blood components during cardiopulmonary bypass (CPB). Concentrating plasma substrate of UF would be beneficial in attenuating CPB-induced dilutional coagulopathy. This study was to investigate whether MUF affected viscoelastic profiles during CPB for cardiac surgery. Patients who underwent elective cardiac surgery and MUF at the end of CPB during January 2019-December 2021 are recruited. Using the patients' electronic medical records, the values of maximum clot firmness of EXTEM assay (MCF-EXTEM) of rotational thromboelastometry (ROTEM) test before and after applying MUF are retrospectively analyzed. As the primary measure, we determine the changes of MCF-EXTEM after applying MUF. With an assumption that MUF increased MCF-EXTEM, the receiver operating characteristic (ROC) analysis is applied to MCF-EXTEM change. The area under the ROC curve is determined and the cut-off value is estimated with specificity and sensitivity in Youden's J statistics. The change of MCF-EXTEM in patients who show MCF-EXTEM less than the cut-off value is analyzed. The changes of hematocrit (Hct) before and after applying MUF is also determined. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05252559
Study type	Observational
Source	Konkuk University Medical Center
Contact
Status	Completed
Phase
Start date	August 1, 2021
Completion date	June 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05308719` - Nasal Oxygen Therapy After Cardiac Surgery	N/A
Recruiting	`NCT06001489` - The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy	N/A
Completed	`NCT02657109` - Influence of a Rehabilitation in Valve Replacement on Heart Rate Variability and Oxidative Stress	N/A
Recruiting	`NCT06154473` - Assessment of Patients Undergoing Cardiac Surgery and Admitted to the Intensive Care Unit
Completed	`NCT03015025` - Pharmacogenetic Dosage Algorithm for Acenocoumarol	N/A
Not yet recruiting	`NCT06076759` - Intrathecal Dexmedetomidine Versus Intrathecal Morphine Inpatients Undergoing Cardiac Valve Replacement Surgeries	N/A
Recruiting	`NCT03825250` - The Val-CARD Trial	Phase 1/Phase 2
Recruiting	`NCT05335902` - Optic Nerve Sheath After Extracorporeal Circulation
Withdrawn	`NCT03446599` - Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery	Phase 2
Recruiting	`NCT04015973` - The PRE-OP ENERGY Trial	N/A
Not yet recruiting	`NCT03440268` - Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement	Phase 4
Not yet recruiting	`NCT06144125` - Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery	Phase 4
Recruiting	`NCT05002543` - CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting
Active, not recruiting	`NCT03810820` - Remote ECG Monitoring of TAVI Patients	N/A
Recruiting	`NCT05206929` - Cardiac Surgery Sternal Precautions	N/A
Terminated	`NCT01236313` - Aortic Wall and Left Ventricular Mechanics: Echocardiographic and Hemodynamic Analysis	N/A
Completed	`NCT04502121` - Preoperative Optimization of Cardiac Valve Patients' Expectations	N/A
Recruiting	`NCT04031144` - Ultrafiltration on Coagulation Function in Cardiac Surgery	N/A
Withdrawn	`NCT04481490` - A Study to Objectively Measure Physical Activity and Sedentary Behavior During Cardiac Rehabilitation
Active, not recruiting	`NCT01783483` - An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative Recovery	Phase 4