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Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass

Cardiac Surgery Clinical Trial

Official title:
High-dose Ulinastatin Improves Postoperative Oxygenation in Patients Undergoing Aortic Valve Surgery With Cardiopulmonary Bypass

Clinical Trial Summary

Retrospective study determine whether ulinastatin enhances postoperative pulmonary oxygenation after cardiopulmonary bypass (CPB).

Clinical Trial Description

This retrospective study evaluate patients who underwent aortic valvular surgery under moderate hypothermic CPB. The patients were classified into two groups: patients in whom high-dose ulinastatin (10,000 U/kg and 5,000 U/kg/h) was administered during CPB (Group-U); and patients in whom ulinastatin was not administered (Group-C). We measured PaO2/FiO2 at the following time points: before CPB (Pre-CPB), 2 hours after weaning from CPB (Post-CPB) and within 6 hours after admission to the ICU. The lengths of ventilator care and ICU stay were also reviewed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03154814
Study type Interventional
Source Konkuk University Medical Center
Contact
Status Completed
Phase Phase 4
Start date January 1, 2016
Completion date May 1, 2017
View Details
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