Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery

Status Completed

Clinical Trial Summary

The purpose of the present research study is to investigate the pharmacokinetics, as well as safety, tolerability and pharmacodynamics of different ascending dosing regimens of AP214 in patients undergoing cardiac surgery. AP214, the investigational drug, is being developed to potentially prevent post-surgical kidney injury after thoracic aortic aneurysm repair.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Aortic Aneurysm
Aortic Root or Ascending Aortic Aneurysm Repair Surgery
Cardiac Surgery
Coronary Artery Bypass Grafting
Valve Surgery

Clinical Trial Details

NCT number	NCT00903604
Study type	Interventional
Source	Action Pharma A/S
Contact
Status	Completed
Phase	Phase 2
Start date	May 2009
Completion date	June 2010

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05054179` - Pecto-Intercostal Fascial Plane Block Catheter Trial for Reduction of Sternal Pain	Phase 2/Phase 3
Completed	`NCT04051021` - Non-Pharmacological Interventions on Patient Experience and Healthcare Utilization in Adult Cardiac Surgery Patients	N/A
Recruiting	`NCT04604886` - The Consistency of Cardiac Output Measured by Pulmonary Artery Catheter and LiDCO in Cardiac Surgical Patients	N/A
Recruiting	`NCT04075981` - Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)	Phase 3
Completed	`NCT04062396` - Comparison of Remowell 2 and Inspire on Delirium and Cognitive Dysfunction	N/A
Recruiting	`NCT04709705` - DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)	Phase 2/Phase 3
Not yet recruiting	`NCT05563662` - SURgical Registry of ENDocarditis EuRope
Withdrawn	`NCT03289104` - Improving Sternal Healing After Cardiac Surgery: Sternal Wire vs ZIPFIX	N/A
Completed	`NCT02964026` - Study of Clinical Outcomes Associated With the Pulmonary Artery Catheter (PAC) in Cardiac Surgery Patients	N/A
Completed	`NCT03563196` - Diagnosis Of Pulmonary Complications After Cardiac Surgery In Children
Completed	`NCT04199039` - Effects of Endotracheal Tube Fixation Methods on Hemodynamic Parameters During Endotracheal Suction	N/A
Completed	`NCT02471001` - The Levels of Anaesthetics in Heart Muscle During Heart Surgery	N/A
Completed	`NCT02325726` - RRI Compared With NephroCheckTM to Predict Acute Renal Failure After Cardiac Surgery.	N/A
Completed	`NCT01246947` - Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation	N/A
Completed	`NCT01151254` - Comparison of Propofol Based Versus Volatile Based Anesthesia and Postoperative Sedation	N/A
Completed	`NCT00996099` - Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients	N/A
Completed	`NCT00821262` - Sevoflurane in Cardiac Surgery	Phase 4
Completed	`NCT00617955` - Effects of Aprotinin During Cardiac Surgery/Long Term Death Rates	N/A
Completed	`NCT00336466` - The Erythropoietin NeuroProtective Effect: Assessment in CABG Surgery (TENPEAKS)	Phase 2
Completed	`NCT00337805` - Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery	Phase 2/Phase 3