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Cardiac Surgery clinical trials

View clinical trials related to Cardiac Surgery.

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NCT ID: NCT04301479 Not yet recruiting - Cardiac Surgery Clinical Trials

Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)

CORTIVAS-CS
Start date: March 2020
Phase: Phase 3
Study type: Interventional

Vasoplegia is an important determinant for adverse postoperative outcome and is observerd in 5% to 54% of patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Postoperative vasoplegia is defined as a state with low systemic vascular resistance despite a normal or high cardiac output, and the need for vasopressor therapy. Steroids attenuate the inflammatory response to cardiopulmonary bypass,but their effect on clinical outcomes is uncertain. This is a double-blinded, randomized, clinical trial designed to determine the efficacy of low dose corticosteroid infusion in vasopressor free-days in vasoplegia after cardiac surgery.

NCT ID: NCT04298580 Not yet recruiting - Cardiac Surgery Clinical Trials

Timing Effect of Ultrasound-Guided PVB After Robotic Cardiac Surgery

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

This study is to evaluate whether the administration of ultrasound-guided paravertebral block (PVB) after surgery would produce better postoperative pain control and fast postoperative recovery after Robotic cardiac surgery. Half of participants will receive PVB before surgery, while the other half will receive PVB at the end of surgery.

NCT ID: NCT04157647 Not yet recruiting - Cardiac Surgery Clinical Trials

Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response

IMHeS
Start date: November 15, 2020
Phase: N/A
Study type: Interventional

Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which increases the risk of death after cardiac surgery. High interleukin 6 (IL-6) blood levels is commonly observed in patients with CKD, and this is particularly high after cardiac surgery. High IL-6 levels are also associated with increased long-term mortality rate after cardiac surgery. To date, the use of ultrafiltration or endotoxin adsorption systems were not found to improve the clinical outcome, although able to reduce the inflammatory mediators concentrations. In the last years, a new extracorporeal hemadsorption filter (CytoSorb) has been developed for removal of inflammatory cytokines and it has been approved by the European Union. However, data lack about the impact on clinical outcome of the use of CytoSorb in patients with CKD undergoing cardiac surgery with cardio-pulmonary bypass (CPB). The investigators have therefore designed this pilot prospective randomized trial to evaluate the efficacy the intraoperative use of CytoSorb for cytokines removal to prevent the inflammatory response associated with the cardiac surgery and complications in patients with CKD.

NCT ID: NCT04028024 Not yet recruiting - Cardiac Surgery Clinical Trials

Protective Effect in Cardiac Surgery Patients

Start date: August 1, 2019
Phase: N/A
Study type: Interventional

The purpose of the study was to verify the protective effect of inhibiting systemic inflammatory response in patients undergoing cardiac surgery.

NCT ID: NCT03905213 Not yet recruiting - Cardiac Surgery Clinical Trials

Prevention of Surgical Wound Infection

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

To compare cost effectiveness of a polyurethane dressing or a vacuum therapy dressing versus the conventional gauze in the prevention of superficial wound infection y major cardiac surgery

NCT ID: NCT03857217 Not yet recruiting - Cardiac Surgery Clinical Trials

Post-Cardiotomy Extra-Corporeal Life Support Study

PELS
Start date: March 2019
Phase:
Study type: Observational

Extracorporeal life support is increasingly used after cardiac surgery. Despite improved technology, outcome still remains poor. This retrospective multicenter cohort study aims to find the (risk) factors associated with the poor prognosis of these patients. Adult patients who received ECLS after cardiac surgery between 2000 and 2018 are eligible for inclusion

NCT ID: NCT03521167 Not yet recruiting - Cardiac Surgery Clinical Trials

Multimodal Analgesia Versus Traditional Opiate Based Analgesia

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Pain after cardiac surgery can be moderate to severe with incisions to the sternum and lower extremities, and also the placement of chest tubes. Postoperative pain may contribute to delirium, stress, myocardial oxygen demand supply imbalance, etc. Traditionally postoperative pain management after cardiac surgery has been based on opiate analgesics. However, opiates have many deleterious side effects including nausea/vomiting, ileus, bladder dysfunction, and respiratory depression, which substantially influence patient recovery and may delay discharge after surgery. The current study is designed to evaluate if an opiate sparing multimodal regimen of tylenol, gabapentin, ketamine, lidocaine and dexmedetomidine provided better analgesic effect (pain score, postoperative PCA opioid dose), less side effects (PONV) and improved cardiac surgery outcome (delirium, a-fib, AKI, dysglycemia) compared to a traditional fentanyl and hydromorphine regimen after cardiac surgery. Additionally, it aims to investigate if the benefit of multimodal regimen is achieved by combination of all drugs or all drugs except dexmedetomodine by introducing third group of study patients who will be randomized to all interventions except saline placebo instead of dexmedetomodine infusion.

NCT ID: NCT03316183 Not yet recruiting - Cardiac Surgery Clinical Trials

Cerebral Monitor Guided Therapy on Cerebral Outcomes After Cardiac Surgery

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to compare patients' metabolomic profiles who are managed with a brain monitor that measures cerebral oxygen to those who are managed by conventional measures to hopefully decrease postoperative neurologic and cognitive deficits and improve quality of life.

NCT ID: NCT03128346 Not yet recruiting - Postoperative Pain Clinical Trials

Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

The TTP block is a novel regional anesthetic technique that shows promise in providing analgesia for anterior chest wall incisions and median sternotomy. The investigators hope to show that by providing the TTP block, there will be reduced early postoperative pain, reduced sedation and shallow breathing, reduced time on breathing machine, leading to an increase in patient comfort and satisfaction. The investigators also hope the decreased need for pain medication and reduced time on the breathing machine will translate into decreased nursing workload.

NCT ID: NCT03075774 Not yet recruiting - Cardiac Surgery Clinical Trials

Observational Study About the Use of Fibrinogen in Adult Cardiac Surgery

Start date: March 2017
Phase: N/A
Study type: Observational [Patient Registry]

Multicenter prospective observational study, involving all adult patients who underwent cardiac surgery with extracorporeal circulation