Cardiac Pacing, Artificial Clinical Trial
Official title:
Trans-coronary Pacing to Assess Myocardial Viability
Narrowing of the coronary arteries can cause chest pain and weaken the heart. In patients who
have had heart attacks, blocked or severely narrowed arteries should be investigated (with
coronary artery x-rays, or angiography) with efforts undertaken to improve the blood flow
(angioplasty and stenting or heart bypass surgery). Sometimes these arteries are in fact
supplying heart tissue which is already dead. Procedures to open up these vessels will
therefore not influence how the patient feels or their future prognosis. On occasion, in
order to determine whether heart tissue is alive (viable) and likely to benefit from of such
efforts, a further investigation is required before another attempt is undertaken to open up
these diseased arteries. This will require imaging of the heart to assess the state of the
tissue (for example with magnetic resonance imaging, or cardiac MRI which is the gold
standard). This means that patients may require two invasive procedures. One way around this
would be to assess the electrical properties of the heart muscle in question during a single
procedure. The principle is simply that dead muscle will have no electrical activity.
Assessing the electrical properties of the heart through the coronary arteries using the same
equipment used to treat the diseased artery during initial coronary angiography may provide
viability information instantly, thus allowing treatment to proceed at the same procedure. In
order to investigate whether this approach has promise, we will be performing a cardiac MRI
around the time that patients have their coronary angioplasty. The electrical data will be
compared to the cardiac MRI results to determine if this technique can be used in clinical
practice. This innovative work has potential clinical and financial benefits.
Furthermore, patients can be diagnosed and treated during one procedure
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04505384 -
Acute Effects of LBBP Versus BVP for CRT
|
N/A | |
| Completed |
NCT00323661 -
Closed Loop Stimulation, Cognitive Performance, and Quality of Life in Pacemaker Patients
|
Phase 4 | |
| Completed |
NCT00399594 -
Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therapy.
|
Phase 2/Phase 3 | |
| Recruiting |
NCT03184233 -
Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Study Concerning the Safety for Heart and Brain
|
N/A | |
| Completed |
NCT03388281 -
Morbidity, Mortality and Gender Differences in Patients With Pacemakers
|
N/A | |
| Terminated |
NCT00422669 -
Optimize RV Selective Site Pacing Clinical Trial
|
N/A | |
| Completed |
NCT00541541 -
Acoustic Cardiographic Assessment of Heart Function and the Role of Phrenic Nerve Stimulation
|
N/A | |
| Completed |
NCT03281395 -
Rapid Ventricular Pacing During Cerebral Aneurysm Surgery: a Retrospective Study Concerning the Safety for Heart and Brain
|
N/A | |
| Terminated |
NCT00116987 -
Dual Chamber Versus Single Chamber Cardiac Pacing in People 80 Years of Age and Older
|
N/A | |
| Completed |
NCT03452462 -
Electrical Resynchronization and Acute Hemodynamic Effects of Direct His Bundle Pacing Compared to Biventricular Pacing
|
N/A |