PLR in a Good Helath After 24 Week of Preganancy

Cardiac Output, High Clinical Trial

Official title:

PLR in a Good Helath Women After 24 Week of Preganancy

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05646342
• Other study ID #: SAR
• Status: Not yet recruiting
• Start date: January 1, 2023
• Est. completion date: April 1, 2023

Study information

• Verified date: December 2022
• Source: Mohammed VI University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

fluid resuscitation is one of the bases of strategies in ICU to take in charge patients , one of the technique to evaluate preload charge , is Passive leg raising, that allows reliable prediction of fluid responsiveness even in patients with spontaneous breathing activity or arrhythmias .

In recent years, hemodynamic response to passive leg raising (PLR) has been popularized as a dynamic test of preload responsiveness [1]. This manoeuvre provides an "auto-fluid challenge" which is rapid, transient and reversible. PLR transfers blood contained in the venous reservoir of the lower extremities to the central venous compartment leading to a transient increase in preload and an increase in cardiac output by Frank-Starling mechanism in preload responsive individuals.

untille now the usseuful of PLR in Pregnancy, and also The validity of dynamic measurements of preload to predict fluid response during pregnancy are note clear in littérature .

Description:

A total of 108 low-risk pregnant women and 54 healthy non-pregnant controls, aged >18 years, participated in the study. Pregnant women attending for the second trimester routine ultrasound screening at 17-19 weeks of gestation were informed about the study and invited to participate if they had a low-risk pregnancy and ultrasound scan did not show any fetal or placental abnormality. Those who agreed were consecutively enrolled and an appointment was made for functional hemodynamic evaluation at 22-24 weeks of gestation. Exclusion criteria were any pre-existing medical condition that may have an effect on the course of pregnancy, and a previous history of preeclampsia, gestational diabetes, intrauterine fetal growth restriction or preterm delivery. Non-pregnant controls were recruited among the nursing, administrative and laboratory staff of the hospital and university. Healthy women of reproductive age were asked to attend for hemodynamic assessment during the follicular phase between day 5 and 10 of the menstrual cycle. Women with a previous history of pregnancy complication and those with a known disease or on regular medication were excluded. Examination was performed,

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: April 1, 2023
• Est. primary completion date: March 30, 2023
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All Pregnante Women in good health after 24 week of preganancy

Exclusion Criteria:

• All young women under 18 years old

• unhealthy women

Related Conditions & MeSH terms

• Cardiac Output, High

Intervention

Other:
• Measure of CO by ECHocardiac Machine
we will realise ETT before and after PLR in all women that eligible of crieria inclusion , in obstetric consultation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Mohammed VI University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PLR in a good helath after 24 week of preganancy	we will realise ETT before and after PLR in all women that eligible of crieria inclusion , in obstetric consultation	in all the 5 mounths