Correlation Between Cardiac Markers and Severity of COVID-19

Cardiac Event Clinical Trial

Official title:

Correlation Between Cardiac Markers and Severity of COVID-19 in Egyptian Population

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05040750
• Other study ID #: FMASU R 150 / 2021
• Status: Recruiting
• Start date: September 1, 2021
• Est. completion date: July 30, 2023

Study information

• Verified date: February 2023
• Source: Ain Shams University
• Contact: Rania M Hussien, MD
• Phone: 026213948
• Email: drrania_maamon[@]med.asu.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

By July 9, 2020, the global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection had resulted in over 11.8 million confirmed cases and over 545000 deaths. Patients with a history of cardiovascular disease are especially vulnerable and have a bad prognosis. According to the findings, cardiac injury manifested by cardiac biomarker elevation is detected in a significant number of COVID-19 patients and is linked to poor outcomes and mortality. However, it is unclear how effective cardiac biomarkers are in COVID-19 prognosis and how to use these indicators.

Description:

The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to >11.8 million confirmed cases with >545000 deaths worldwide by July 9, 2020 Patients with preexisting cardiovascular conditions are particularly at risk and have poor prognosis data suggest that cardiac injury, manifested by cardiac biomarker elevation, is detected in a sizable of COVID-19 patients and is associated with adverse outcomes and increased mortality. However, how useful cardiac biomarkers are in COVID-19 prognosis and how to utilize these markers have not been well defined The study will include all moderate to severe COVID 19 patients admitted to ICU. Both genders within the age group 18-60 years were included. The primary outcome is the relation between cardiac markers and mortality rate in critically ill COVID 19 patients The secondary outcome is the relationship between cardiac and inflammatory and coagulation markers

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 207
• Est. completion date: July 30, 2023
• Est. primary completion date: July 30, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• all moderate to severe COVID 19 patients who were admitted to ICU.

• Both genders

• age group 18-60 years

Exclusion Criteria:

• a refusal to participate in the study,

• pregnant patients,

• patients aged <18 or >60. years,

• recent history of acute myocardial infarction (< 1 month before admission).

Related Conditions & MeSH terms

• Cardiac Event

Intervention

Other:
• laboratory investigation
observe the relation between cardiac markers and mortality rate in critically ill COVID 19 patients

Locations

Country	Name	City	State
Egypt	Ain Shams University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	relation between cardiac markers and mortality rate in critically ill COVID 19 patients	relate cardiac biomarkers to mortality rate	4 month
Secondary	relation ship between cardiac and inflammatory and coagulation markers	compare cardiac markers to inflammatory and coagulation laboratory findings	4 month