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Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa — DEMO  

Carcinoma, Squamous Cell Clinical Trial

Official title:
Tobacco and Alcohol Influence on Oncogenic Drivers and Somatic Evolution in the Oral Mucosa

Clinical Trial Summary

Head and neck cancers represent more than 500,000 cases per year worldwide, and often involve post-treatment relapse. The oral cavity is the most frequent site, but early disease stages are still insufficiently characterised and poorly detected. The study's aim is to better understand the oral mucosa somatic evolution, and how it can give rise to oral squamous cell carcinoma (OSCC). This is a multi-centric, descriptive, non-interventional cohort in healthy adult subjects. The aim of the study is to detect the presence of OSCC driver gene mutations in healthy subjects' oral mucosa, quantify whether they provide cells with a selective advantage, and study the impact of tobacco and alcohol consumption on the mutational load. This study will not allow to identify potential malignant cells, and will be usable for diagnostic purposes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06094829
Study type Observational
Source Hospices Civils de Lyon
Contact Brigitte MD GROSGOGEAT
Phone 04 78 77 86 89
Email brigitte.grosgogeat@univ-lyon1.fr
Status Not yet recruiting
Phase
Start date November 15, 2023
Completion date November 15, 2024
View Details
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