Carcinoma, Squamous Cell Clinical Trial
Official title:
The Clinical Study of the Poorly Differentiated Head and Neck Squamous Cell
Head and neck Squamous Cell Carcinoma (HNSCC) is one of the most common head and neck malignant tumors .Investigators found that several patients with early TNM stage and poor differentiated HNSCC had poor prognosis, yet someone with advanced TNM stage and well differentiated HNSCC had good prognosis. Hence, Investigators suggested that prognosis factors and survival rates probably related to the differentiation of HNSCC, and prognosis factor of poorly differentiated HNSCC were rare discussed and controversy. Investigating the prognostic factors of poorly differentiated HNSCC is undoubtedly crucial.
Head and neck Squamous Cell Carcinoma (HNSCC) is one of the most common head and neck
malignant tumors. Investigators found that several patients with early TNM stage and poor
differentiated HNSCC had poor prognosis, yet someone with advanced TNM stage and well
differentiated HNSCC had good prognosis. Hence, Investigators suggested that prognosis
factors and survival rates probably related to the differentiation of HNSCC, and prognosis
factor of poorly differentiated HNSCC were rare discussed and controversy. Investigating the
prognostic factors of poorly differentiated HNSCC is undoubtedly crucial.
About this study ,inclusion criteria were the following parts:
the patients of poor differentiated HNSCC ; T1-4aN0-2M0; pathological examination: poor
differentiated squamous cell carcinoma; initial treatment(primary, without surgery,
radiotherapy and chemotherapy); range:18-70 years old; KPS>80; hemogram and the function of
main organ such as heart, lung, liver and kidney were normal; having the endoscopy, CT and
MRI before formed into different groups; sign the informed consent file, good compliance.
AND the exclusion criteria were:
uncontrollable epileptic seizure, disorder of central nervous system or unconsciousness
cause by psychosis; serious and uncontrollable infection; main organ system failure
(including heart ,lung ,liver and kidney); reject training; high and moderate differentiated
squamous cell carcinoma
;
Observational Model: Case Control, Time Perspective: Prospective
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