Mechanistic Evaluation on Sorafenib Induced Hypophosphatemia.

Carcinoma, Renal Cell Clinical Trial

Official title:

Mechanistic Evaluations on Sorafenib Induced Hypophosphatemia in Patients With Advanced Renal Cell Carcinoma

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00622479
• Other study ID #: 12345
• Status: Terminated
• Phase: Phase 1
• First received: February 13, 2008
• Last updated: December 17, 2014
• Start date: May 2008
• Est. completion date: November 2010

Study information

• Verified date: December 2014
• Source: Bayer
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to:

1. To elucidate the mechanism involved in the sorafenib-induced hypophosphatemia and possible early effect of hypophosphatemia on bone mineral density

2. A secondary objective to assess the effect sorafenib treatment on evaluate left ventricular function (LVEF) and Beta-type natriuretic peptide in plasma.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 12
• Est. completion date: November 2010
• Est. primary completion date: October 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age >/= 18 years

• Histologically or cytologically confirmed advanced RCC

• Evaluable disease with lesions measured by CT-scan or MRI according to modified Response Evaluation Criteria in Solid Tumors (RECIST)

• ECOG Performance Status of 0 or 1

• Adequate bone marrow, liver and renal functions as assessed by the following laboratory requirements to be conducted within 7 days prior to screening:

• Hemoglobin > 9.0 g/dL 1. Age greater Than 18 yrs old

• Absolute neutrophil count (ANC) > 1,500/mm3

• Platelet count 100,000/mm3

• Total bilirubin <= 1.5 times the upper limit of normal

• ALT and AST <= 2.5 x upper limit of normal (<= 5 x upper limit of normal for patients with liver involvement of their cancer)

• Amylase and lipase < 1.5 x the upper limit of normal

• PT-INR/PTT 1.5 x ULN (Patients who are being prophylactically anti-coagulated with an agent such as coumadin or low molecular weight heparin or therapeutically anti-coagulated with LMWH will be allowed to participate provided that they meet these criteria; in addition, these patients must be monitored at appropriate intervals throughout study)

• Serum creatinine < 2.0 x the upper limit of normal or creatinine clearance (CrCl) 45 mL/min (CrCl = Wt (kg) (140-age)/72 Cr level, female 0.85) for patients with creatinine levels above 2.0 x ULN

• Phosphate 2.0 mg/dl

• LVEF >/= 40%

• Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of treatment. Negative results must be available prior to study treatment

• Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation, including the 30 day period after last study drug dosing. The investigator should advise the patient how to achieve adequate contraception

• Signed informed consent must be obtained prior to any study specific procedures

Exclusion Criteria:

• Patients who meet the following criteria at the time of screening will be excluded:

• History of cardiac disease: congestive heart failure >NYHA Class 2; hospitalization for CHF symptoms in the 6 months prior to study entry; active CAD (MI more than 6 months prior to study entry is allowed); cardiac arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are permitted) or uncontrolled hypertension

• Known history of HIV infection or chronic hepatitis B or C

• Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical management

• Active clinically serious infections (> Grade 2 CTCAE v3)

• Known history or presence of metastatic brain or meningeal tumors (head CT or MRI at screening to confirm)

• Patients with seizure disorder requiring medication (such as steroids or anti epileptics)

• History of organ allograft

• Patients undergoing renal dialysis

• Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study EXCEPT cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors [Ta, Tis & T1] or any cancer curatively treated > 3 years prior to study entry

• Anticancer chemotherapy or immunotherapy during the study or within 4 weeks of study entry. Mitomycin C or nitrosureas should not be given within 6 weeks of study entry. Anticancer therapy is defined as any agent or combination of agents with clinically proven anticancer activity administered by any route with the purpose of affecting the cancer, either directly or indirectly, including palliative and therapeutic endpoints

• Radiotherapy to target lesions within 4 weeks of start of study drug

• Major surgery within 4 weeks of start of study

• Serious, non-healing wound, ulcer, or bone fracture

• Investigational drug therapy within 4 weeks of study entry

• Prior exposure to sorafenib

• Pregnant or breast-feeding patients

• Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results

• Known or suspected allergy to the investigational agent or any agent given in association with this trial

• Any condition that is unstable or could jeopardize the safety of the patient and their compliance in the study

• Unable to swallow oral medications

• Any malabsorption condition

• Current treatment with bisphosphonates therapy or prior therapy with such agents within 12 weeks of enrollment

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Carcinoma, Renal Cell
• Hypophosphatemia

Intervention

Drug:
• Sorafenib (Nexavar, BAY43-9006)
Sorafenib will be administered at 400mg BID for a 28 day cycle.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Bayer

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To evaluate a potential mechanism of hypophosphatemia related to sorafenib treatment based on measurement of phosphate regulating factors, peptides, and related laboratory variables		Occur when the last query is resolved	Yes
Secondary	To assess the effect of sorafenib treatment on left ventricular ejection fraction (LVEF) and B-type Natriuretic Peptide (BNP) in plasma		Occur when the last query is resolved	Yes

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