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Clinical Trial Summary

Akkermansia muciniphila is a naturally occurring bacterium found in the healthy human gastrointestinal tract. Analysis of the gut microbiota of NSCLC or RCC patients shows that the presence of Akkermansia is associated with the clinical efficacy of immunotherapy. In preclinical models, oral administration of the Akkermansia p2261 strain reverses resistance to PD-1 blockade. In the clinical setting, it is therefore hypothesized that the oral administration of Oncobax®-AK to cancer patients under immunotherapy, but whose gut microbiota is deficient in Akkermansia will restore / improve the efficacy of immunotherapy in patients with NSCLC or RCC.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05865730
Study type Interventional
Source EverImmune
Contact Alain Thibault, MD
Phone +32472196345
Email alain.thibault@everimmune.com
Status Recruiting
Phase Phase 2
Start date October 1, 2022
Completion date June 2026

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