Intra-patient Dose Escalation Study of Sorafenib in Advanced Non-small Cell Lung Cancer

Carcinoma, Non Small Cell Lung Clinical Trial

Official title:

A Phase I, Intrapatient Dose-Escalation Study of Sorafenib in Advanced or Relapsed Non-Small Cell Lung Cancer (NSCLC)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00954278
• Other study ID #: CO08511
• Secondary ID: H-2009-0011IST 0
• Status: Completed
• Phase: Phase 1
• Start date: July 28, 2009
• Est. completion date: December 23, 2015

Study information

• Verified date: March 2019
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the number of patients with advanced, relapsed non-small cell lung cancer who can tolerate dose escalation sorafenib from 400 mg twice daily to either 600 mg twice daily or 800 mg twice daily. Safety and tolerability of sorafenib will also be examined.

Description:

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality in the U.S. Time to progression in advanced disease remains poor and further study of newer agents with novel mechanisms of action is needed to improve duration and quality of life for NSCLC patients.

Sorafenib is an oral-multi-kinase inhibitor with effects on tumor proliferation and tumor angiogenesis. Sorafenib has demonstrated activity in preclinical models of NSCLC both in combination with chemotherapy and as monotherapy. A recent intra-patient dose escalation trial of sorafenib in renal cell carcinoma showed positive response rates and tolerability up to 1200mg in 91% of patients.

This study attempts a similar dose-escalation of sorafenib in NSCLC patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: December 23, 2015
• Est. primary completion date: December 23, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Histologically or cytologically confirmed, advanced (stage IIIB with pleural effusion, stage IV, or recurrent), kras mutation positive, non-small cell lung cancer (NSCLC)

• Measurable disease per RECIST criteria

• Patients must have received one + prior chemotherapy regimens for NSCLC

• Patients may have treated and clinically stable brain metastases

• Adequate bone marrow, liver and renal function

• Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to the start of treatment

• Women of childbearing potential and men must agree to use adequate contraception (barrier method of birth control) prior to study entry and for the duration of study participation, and for 3 months after last administration of sorafenib

• Patients must have the ability to understand and willingness to sign a written informed consent

• International normalized ratio(INR) < 1.5 or prothrombin time/ partial thromboplastin time (PT/PTT) within normal limits

Exclusion Criteria:

• Prior exposure to a Ras pathway inhibitor

• Any other anti-tumor therapy within 3 weeks of enrollment

• Prior bevacizumab within the past 6 weeks

• An active secondary malignancy except non-melanoma skin cancer

• Cardiac disease: Congestive heart failure > class II NYHA. Patients must not have unstable angina or new onset angina or myocardial infarction within the past 6 months

• Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

• Uncontrolled hypertension, defined as systolic blood pressure > 150mm Hg or diastolic pressure > 90mm Hg, despite optical medical management

• Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C

• Active clinically serious infection > Common Terminology Criteria for Adverse Events (CTCAE) Grade 2

• Thrombolic or embolic events such as cerebrovascular accident including transient ischemic attack within the past 6 months

• Pulmonary hemorrhage/bleeding event >/= CTCAE Grade 2 within 4 weeks of first dose of study drug

• Any other hemorrhage/bleeding event >/= CTCAE Grade 3 within 4 weeks of first dose of study drug

• Serious non-healing wound, ulcer, or bone fracture

• Evidence or history of bleeding diathesis or coagulopathy

• Major surgery, open biopsy or significant traumatic injury within 4 weeks of first study drug

• Use of St. John's Wort or rifampin

• Known or suspected allergy to sorafenib or any agent given in the course of the trial

• Any condition that impairs patient's ability to swallow whole pills

• Any malabsorption problem

Related Conditions & MeSH terms

• Carcinoma, Non Small Cell Lung
• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms

Intervention

Drug:
• sorafenib
sorafenib (400mg or 600mg or 800mg) by mouth twice daily, for 28 days

Locations

Country	Name	City	State
United States	University of Wisconsin - Madison	Madison	Wisconsin

Sponsors (2)

Lead Sponsor	Collaborator
University of Wisconsin, Madison	Bayer

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Toleration of dose escalation (dose-limiting toxicities)		One year
Secondary	Safety of sorafenib in dose-escalation (adverse events and serious adverse events)		One year

External Links

•   University of Wisconsin Carbone Cancer Center