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Clinical Trial Summary

The goal of this clinical trial is to test the safety and effectiveness of a medical device called 166-Holmium microspheres (QuiremSpheres®) in patients with hepatocellular carcinoma (HCC) . The main questions it aims to answer are: - What is the safety and toxicity profile of the 166-Holmium microspheres? - Is the device effective in treating HCC? Participants will undergo a range of screening procedures to confirm they are eligible and to record their baseline results, including: - A Computed Tomography (CT) scan - A Magnetic Resonance Imaging (MRI) scan - Blood tests - Quality of life questionnaires Before receiving treatment with QuiremSpheres® the participant will receive a 'scout' dose of the microspheres, to check whether there is distribution of the radioactivity to other non-target areas of the body. This is measured using Single-Photon Emission Computed Tomography-CT imaging. If the distribution to non-target areas is deemed to not be too high, the participant will go on to receive the individualised therapeutic dose of QuiremSpheres®. Follow-up visits will occur 3 and 6 weeks post-treatment dose, and then at 3 and 6 months.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06302400
Study type Interventional
Source Imperial College London
Contact Rohini Sharma, Professor
Phone 02033133720
Email r.sharma@imperial.ac.uk
Status Recruiting
Phase N/A
Start date February 22, 2024
Completion date February 2027

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