Carcinoma, Hepatocellular Clinical Trial
Official title:
Study of Hepatocellular Carcinoma Risk in Patient With Liver Cirrhosis
Purpose of the study is to determine transcriptomics, metabolomics and proteomics features of liver cirrhotic tissue in patients with hepatocellular carcinoma (HCC) and to find a correlation with the risk of developing HCC and survival.
Patients will be enrolled after hepatic ultrasonography control and they will be submitted to
hepatic vein pressure gradient and liver biopsy.
The study have four research lines:
Task # 1: transcriptomic characterization of liver tissue. During hepatic vein pressure
gradient , liver tissue will be extracted with transjugular catheter equipped with a biopsy
device. Tissue will be used to extract microRNA to define molecular signature.
Task # 2: Proteomic characterization of liver tissue. Protein expression changes will be
analyze with MALDI-TOF
Task # 3: Metabolomic features on serum of patient with cirrhosis. Metabolomics is defined as
the quantitative measurement of the dynamic multiparametric response of living systems to
pathophysiological stimulus or genetic modification. Principal objective of this activity
will be identify metabolites deregulated with metabolomic approach and clarify any new
pathways involved in the evolution of cirrhosis to hepatocellular carcinoma.
The metabolomic analysis will be performed on sera collected in patients with cirrhosis at
baseline.
Task # 4: Transcriptomic characteristics of newly diagnosed HCC. New diagnosis of
hepatocellular carcinoma will undergo an eco-assisted liver biopsy. A tissue sample will be
dedicated to the extraction of 'RNA. Patients will then undergo elective treatment according
to international guidelines. The course of the disease and the results of therapeutic
interventions will be recorded and correlated with the molecular data. Molecular signature
will be obtain.
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