Carcinoma, Hepatocellular Clinical Trial
Official title:
Circulating Tumor Cells (CTCs) as Biomarkers of Prognosis and Predictors of Efficacy of Drug Therapy for Patients With Hepatocellular Carcinoma
To explore the clinical value of circulating tumor cells (CTCs) measurement for Hepatocellular carcinoma (HCC) patients.
Background:The lack of tumor tissue for drug target and biomarker studies significantly
limit the development of novel treatment for advanced HCC. In recent years, circulating
tumor cells (CTCs) have been shown to be important prognostic biomarkers of overall survival
for patients with breast, prostate, and colorectal cancer after anti-cancer therapy.
Methods and Materials:This project plans to enroll 50 HCC patients who receive curative
surgery or radiofrequency ablation therapy, 50 patients who receive trans-arterial
chemoembolization, and 50 patients who receive systemic therapy at National Taiwan
University Hospital in 24 months for CTCs analysis. The eligible patients will receive blood
tests before and after anti-cancer therapy. The blood samples will be separated to blood
cells and plasma. Blood cells will be used for isolation and enumeration of CTCs. Plasma
will be used to extract DNA to measure molecular aberration (gene mutations related to
hepatocarcinogenesis or response of HCC cells to molecular targeted therapy)
1. to explore the correlation between CTCs numbers and other clinical characteristics in
HCC patients with different stages;
2. to compare the patterns of molecular aberrations between CTC and HCC tumor tissue in
HCC patients who have archival tumor tissue available; and
3. to measure the changes of CTCs numbers and molecular aberrations in HCC patients before
and after molecular targeted therapy.
;
Observational Model: Case-Only, Time Perspective: Prospective
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