Comparison of the Effectiveness of Treatments in Carbon Monoxide

Status Recruiting

Clinical Trial Summary

Carbon monoxide (CO) poisoning is a condition that occurs as a result of inhaling carbon monoxide gas and can potentially lead to serious health issues. The treatment of CO poisoning requires urgent medical intervention. Methods used in the treatment of CO poisoning include normobaric oxygen (oxygen at normal pressure), high-flow oxygen, non-invasive continuous positive airway pressure (CPAP), and hyperbaric oxygen therapy. Studies on these methods are available in the literature.

Clinical Trial Description

When examining the mechanisms of application for these methods: Normobaric Oxygen Therapy: In normobaric oxygen therapy, researchers treat participants with normobaric (sea level) oxygen. This method provides high concentrations of oxygen, allowing better oxygen saturation of the blood and faster removal of carbon monoxide from the body. Participants inhale normobaric oxygen through devices such as masks or nasal cannulas. High-Flow Oxygen Therapy: In high-flow oxygen therapy, researchers treat participants with high-flow oxygen. Typically, a nasal cannula or oxygen mask is used. The high flow rate allows more oxygen to reach the alveoli and bind to hemoglobin. This method can be effective, especially in more severe cases of carbon monoxide poisoning. Non-Invasive CPAP Therapy: Non-invasive CPAP therapy is typically used to treat respiratory problems such as sleep apnea but can also be used in the treatment of CO poisoning. Participants receive oxygen under continuous positive airway pressure with the help of a mask. Comparison of these methods: Normobaric oxygen is considered the standard treatment for CO poisoning and generally effectively eliminates carbon monoxide from the body. High-flow oxygen may be more effective in providing additional oxygen in more severe cases, but it works similarly to normobaric oxygen. The choice of which treatment method to use can vary depending on the participant's clinical condition, the severity of poisoning, and other factors. The researchers main goal in designing this study is to determine which treatment, depending on the researcher's decision, most rapidly shortens the half-life of carbon monoxide in participants experiencing severe carbon monoxide poisoning.The researchers aim to identify which treatment participants tolerate better and which method minimizes complications related to CO intoxication. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06198595
Study type	Observational
Source	Ankara City Hospital Bilkent
Contact	SAFA DÖNMEZ, MD
Phone	+90 553 751 55 45
Email	drsafa0131@gmail.com
Status	Recruiting
Phase
Start date	December 20, 2023
Completion date	June 30, 2024

View Details

See also
Status	Clinical Trial	Phase
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Recruiting	`NCT04975867` - Adjunct Targeted Temperature Management in Acute Severe Carbon Monoxide Poisoning	N/A
Terminated	`NCT01099995` - Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning	Phase 3
Terminated	`NCT01100515` - Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning	Phase 3
Terminated	`NCT03017742` - Utility of Non-invasive Carboxyhemoglobin and Total Hemoglobin Measurement in the Emergency Department
Terminated	`NCT01059708` - Outcome Following Carbon Monoxide Poisoning in Children	N/A
Recruiting	`NCT05591300` - Microparticles Blood Level in Acute Carbon Monoxide Poisoning
Not yet recruiting	`NCT04475263` - Cognitive and Blood Biomarker Assessment After CO Exposure
Completed	`NCT03926494` - Carbon Monoxide-induced Coma: Prognostic Factors
Recruiting	`NCT02375126` - Normal Quantitative EEG (qEEG) Dataset
Completed	`NCT03342209` - Utility of High Flow Nasal Cannula in CO Toxicity	N/A
Completed	`NCT00465855` - One vs. Three Hyperbaric Oxygen Treatments for Acute Carbon Monoxide Poisoning	Phase 4
Recruiting	`NCT04490317` - CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)
Withdrawn	`NCT04118491` - Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy	N/A
Unknown status	`NCT00841165` - Carbon Monoxide Monitoring and Emergency Treatment	N/A
Withdrawn	`NCT00280579` - Cyanide Poisoning in Fire Victims	N/A
Enrolling by invitation	`NCT02483650` - Hyperbaric Oxygen Therapy Registry
Completed	`NCT05088005` - Prognostic Biomarkers in CO Poisoning
Completed	`NCT03030833` - Dysfunctional Hemoglobin Pulse Oximetry	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison of the Effectiveness of Treatments in Carbon Monoxide Intoxications

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms