Carbon Monoxide Poisoning Clinical Trial
— COMPsOfficial title:
Microparticles Blood Level in Acute Carbon Monoxide Poisoning
The goal of this pilot, clinical, experimental, biological and prospective study with uso of biological material (venous blood sampling), in patient with acute carbon monoxide (CO) intoxication and in a group of healthy non-intoxicated subject (group of control) is the research of a possible increase of circulating microparticles level in human blood with an acute carbon monoxide intoxication. The main question to answer is: Is there an increase of circulating microparticles levels in subjects with acute carbon monoxide poisoning? Two blood samples will be withdrawn from patients with acute carbon monoxide poisoning, one before and one after hyperbaric oxygen treatment. Researchers will compare a group of healthy volunteers to see if there is a different in circulating microparticles blood level compared to patients with intoxication.
Status | Recruiting |
Enrollment | 108 |
Est. completion date | November 15, 2025 |
Est. primary completion date | November 15, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - Age > 18 years - Acute carbon monoxide poisoning - Need for treatment with hyperbaric oxygen Exclusion Criteria: - Patient reject to consent |
Country | Name | City | State |
---|---|---|---|
Italy | AOU Maggiore della Carità | Novara |
Lead Sponsor | Collaborator |
---|---|
Azienda Ospedaliero Universitaria Maggiore della Carita | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Microparticles research | Quantify the number and the type of circulating microparticles in subjects after carbon monoxide poisoning. | 2 years | |
Secondary | Relationship between poisoning severity and circulating microparticles levels | Evaluate the possible relationship between carbon monoxide poisoning severity measured as COHb levels and circulating microparticles levels before and after hyperbaric oxygen treatment. | 45 days | |
Secondary | Risk factors of delayed neurological syndrome development | Research of risk factors of delayed neurological syndrome development and follow up with test of Pfeiffer. | 45 days | |
Secondary | Proteomic and transcriptomic analysis | Researche the type of microparticles with proteomic and transcriptomic analysis | 2 years |
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