Carbon Monoxide Poisoning Clinical Trial
Official title:
Role of Pulse Co-oximetry in Prehospital Emergency Medical Service Management of Suspected Carbon Monoxide Poisoning : A Prospective Multicenter Study.
The RAD-57 pulse CO-oximeter is a lightweight device allowing non-invasive measurement of
blood carboxyhemoglobin. Previous studies comparing RAD-57 measurements (SpCO) to standard
laboratory blood gas analysis (COHb) have reported contradictory results.
the RAD-57 pulse CO-oximeter could be useful as a first-line screening test for acute CO
poisoning, enabling rapid detection and management of patients with suspected CO poisoning
in the prehospital emergency setting This study assesses the diagnostic value of pulse
CO-oximetry, comparing SpCO to standard laboratory blood measurement for prehospital
management of patients with suspected carbon monoxide (CO) poisoning.
Transcutaneous SpCO will be obtained using the RAD-57 simultaneously with blood sampling for laboratory blood gas analysis, at the time of prehospital management by emergency medical services. The diagnostic performance of SpCO for the screening of CO poisoning will be determined using ROC curve analysis, and Blood COHb levels >5% and 10% as the reference standard for CO poisonning for non-smokers and smokers respectively. Correlation between SpCO and COHb will be assessed using Bland and Altman's method. ;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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