Pronase Granules in Gastric Cleaning

Status Recruiting

Clinical Trial Summary

Magnetically controlled capsule endoscopy (MCE) is now widely used all over the world. However, the standard gastric preparation method by dimethicone we used clinically still has mucus at the bottom of the stomach. In this study, we aimed to determine whether pronase granules is helpful to improve the cleanliness of gastric mucosa in MCE.

Clinical Trial Description

As a non-invasive and well-tolerated gastrointestinal examination method, magnetically controlled capsule endoscopy (MCE) is being increasingly used in different populations in recent years. Gastric preparation is extremely important for the completion rate (CR), image quality, and diagnostic efficiency because of the plica of gastric mucosa and the autonomous movement of the capsule in the gastrointestinal tract. After a series of explorations including air-producing powder, defoamer, protease preparation, patients are asked to drink about 800 ml-1000 ml water in a short time for standard gastric filling. However, the existing problems of gastric preparation such as abdominal distension, insufficient gastric filling, and long gastric retention time deserve attention. Different from the results of Zhu et al. (DLD, 2017), the current clinical experience shows that the addition of pronase granules in gastric preparation can often reduce the mucus in the stomach. But the standardized use of pronase granules remains to be further explored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05249933
Study type	Interventional
Source	Changhai Hospital
Contact	Zhuan Liao
Phone	021-31161024
Email	zhuanleo@126.com
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	February 24, 2021
Completion date	March 1, 2022

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