Capsule Endoscopy Clinical Trial
Official title:
SMALL BOWEL CLEANSING FOR CAPSULE ENDOSCOPY IN PEDIATRIC PATIENTS: A PROSPECTIVE RANDOMIZED SINGLE-BLINDED STUDY
The primary aim of this prospective, randomized and controlled study was to evaluate the effect of five bowel preparation regimens on small-bowel cleansing in a pediatric population. The secondary endpoints were to evaluate the safety and the effects of preparation on diagnostic yield of CE.
Capsule endoscopy (CE) is a well-known, non-invasive, diagnostic tool to evaluate small
bowel diseases in adults and children. Unfortunately, because CE does not have functions
which allow suctioning of fluid or washing the small bowel mucosa during the examination,
its diagnostic yield can be limited by presence of debris, biliary secretion, bubbles and
blood in the gut lumen that may hide relevant findings especially in the distal small bowel.
In addition, CE sometimes fails to reach the cecum within the battery life of the capsule,
resulting in a failure to visualize the distal small intestine. However, in children this
problem is less frequent for the increased intestinal motility, which reduces the transit
time of the capsule.
It was believed that cleaning the small intestine prior to examination would improve mucosal
visibility during the endoscopy and, as a result, the diagnostic yield of the technique.
Therefore, proposals were put forward based on preparations for other types of explorations,
such as colonoscopies (2).
Some authors have already studied in adults the effect of bowel preparation on small-bowel
visualization using different agents; the results of the published series are contradictory.
To date, while there is evidence for a benefit from bowel preparation for CE, there is so
far no consensus on an optimal preparation regimen. In addition, in children there are not
studies on this topic. Therefore, overnight fasting before the examination still remains the
proposed preparation for capsule endoscopy.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator)
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